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Titolo:
Lack of effect of soy isoflavone on thyroid hyperplasia in rats receiving an iodine-deficient diet
Autore:
Son, HY; Nishikawa, A; Ikeda, T; Imazawa, T; Kimura, S; Hirose, M;
Indirizzi:
Natl Inst Hlth Sci, Div Pathol, Setagaya Ku, Tokyo 1588501, Japan Natl Inst Hlth Sci Tokyo Japan 1588501 Setagaya Ku, Tokyo 1588501, Japan Showa Womens Univ, Setagaya Ku, Tokyo 1548533, Japan Showa Womens Univ Tokyo Japan 1548533 Setagaya Ku, Tokyo 1548533, Japan
Titolo Testata:
JAPANESE JOURNAL OF CANCER RESEARCH
fascicolo: 2, volume: 92, anno: 2001,
pagine: 103 - 108
SICI:
0910-5050(200102)92:2<103:LOEOSI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENVIRONMENTAL ESTROGENIC COMPOUNDS; PHASE-II ENZYMES; N-BIS(2-HYDROXYPROPYL)NITROSAMINE DHPN; CARCINOGENESIS; SERUM; PHYTOESTROGENS; CHOLESTEROL; THYROXINE; HORMONES; TISSUES;
Keywords:
thyroid; isoflavone; iodine-deficient; soybean;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Son, HY Natl Inst Hlth Sci, Div Pathol, Setagaya Ku, 1-18-1 Kamiyoga, Tokyo 1588501, Japan Natl Inst Hlth Sci 1-18-1 Kamiyoga Tokyo Japan 1588501 501, Japan
Citazione:
H.Y. Son et al., "Lack of effect of soy isoflavone on thyroid hyperplasia in rats receiving an iodine-deficient diet", JPN J CANC, 92(2), 2001, pp. 103-108

Abstract

We have reported a dramatic synergism between soy intake and iodine deficiency regarding induction of thyroid hyperplasia in rats. Because isoflavones are active constituents of soybeans, in the present study, their possiblecontribution was examined, Female F344 rats were divided into 8 groups, exposed to diet containing a 0.2% soy isoflavone mixture (SI), 0.2% SI+iodinedeficiency (ID), 0.04% SI, 0.04% SI+ID, 20% defatted soybean (DS) alone, 20% DS+ID, ID alone or basal diet alone for 5 weeks, Thyroid weight was not influenced by SI, but was increased by the ID and DS diets with a further significant increment in the DS+ID group (P<0.01). Compared to the control value, serum T-4 was significantly (P<0.01) increased by 20% DS alone and decreased in all groups given the ID treatment (P<0.001). Serum thyroid stimulating hormone (TSH) level was increased by ID, and further enhanced by DS (P<0.01) but not SI, Histopathologically; diffuse hypertrophy and/or hyperplasia of thyroid follicles were observed in the ID-treated groups, the severity being enhanced by DS but not SI. Proliferating cell nuclear antigen labeling indices (%) mere elevated in the ID diet groups and again enhanced by DS, but not SI. These results thus suggest that isoflavones may not be involved in the mechanisms underlying the synergistic goitrogenic effect of soybean with iodine deficiency.

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Documento generato il 28/03/20 alle ore 23:19:21