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Titolo:
Serotonin 5-HT2A receptor binding in platelets from patients with Alzheimer's disease or vascular dementia
Autore:
Spigset, O; Wilhelmsson, C; Mjorndal, T; Eriksson, S;
Indirizzi:
Trondheim Reg & Univ Hosp, Dept Clin Pharmacol, N-7006 Trondheim, Norway Trondheim Reg & Univ Hosp Trondheim Norway N-7006 7006 Trondheim, Norway Norrland Univ Hosp, Div Clin Pharmacol, Umea, Sweden Norrland Univ Hosp Umea Sweden v Hosp, Div Clin Pharmacol, Umea, Sweden Norrland Univ Hosp, Dept Geriatr Med, Umea, Sweden Norrland Univ Hosp Umea Sweden niv Hosp, Dept Geriatr Med, Umea, Sweden
Titolo Testata:
INTERNATIONAL PSYCHOGERIATRICS
fascicolo: 4, volume: 12, anno: 2000,
pagine: 537 - 545
SICI:
1041-6102(200012)12:4<537:S5RBIP>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACID DIETHYLAMIDE BINDING; BLOOD-PLATELETS; FRONTAL-CORTEX; AFFECTIVE-DISORDER; SENILE DEMENTIA; DEPRESSION; BRAIN; 5-HYDROXYTRYPTAMINE; CITALOPRAM; SYMPTOMS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Spigset, O Trondheim Reg & Univ Hosp, Dept Clin Pharmacol, N-7006 Trondheim, Norway Trondheim Reg & Univ Hosp Trondheim Norway N-7006 eim, Norway
Citazione:
O. Spigset et al., "Serotonin 5-HT2A receptor binding in platelets from patients with Alzheimer's disease or vascular dementia", INT PSYCHOG, 12(4), 2000, pp. 537-545

Abstract

It is well known that abnormalities in the brain serotonin system exist inpatients with dementia. The present study was performed in order to investigate whether a peripheral serotonin system marker, the platelet 5-HT2A receptor, is affected in dementia. Thirty-eight patients with Alzheimer's disease (AD), 13 patients with vascular dementia, and 40 healthy controls were included in the study. There were no significant differences in receptor density for 5-HT2A receptor binding between the groups. Affinity of the radioligand to the receptor was significantly lower in AD than in vascular dementia and in the controls (p = .006 and p = .003, respectively), whereas there was no significant difference between the vascular dementia group and thecontrol group. In 12 patients, treatment with citalopram was started due to depression or agitation. This treatment significantly reduced the Behavioral Pathology in Alzheimer's Disease Rating Scale scores (p = .001), but did not affect the platelet 5-HT2A receptor status. There was no correlation between 5-HT2A receptor status before treatment and the therapeutic effect of citalopram. The study indicates that platelet 5-HT2A receptor status is of limited value as a peripheral marker in dementia.

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Documento generato il 27/01/20 alle ore 02:30:04