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Titolo:
Radiation-induced acute intestinal inflammation differs following total-body versus abdominopelvic irradiation in the ferret
Autore:
Freeman, SL; Hossain, M; MacNaughton, WK;
Indirizzi:
Univ Calgary, Mucosal Inflammat Res Grp, Calgary, AB T2N 1N4, Canada Univ Calgary Calgary AB Canada T2N 1N4 s Grp, Calgary, AB T2N 1N4, Canada Univ Calgary, Dept Physiol & Biophys, Calgary, AB T2N 1N4, Canada Univ Calgary Calgary AB Canada T2N 1N4 ophys, Calgary, AB T2N 1N4, Canada
Titolo Testata:
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
fascicolo: 3, volume: 77, anno: 2001,
pagine: 389 - 395
SICI:
0955-3002(200103)77:3<389:RAIIDF>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
EVOKED ELECTROLYTE TRANSPORT; NITRIC-OXIDE SYNTHASE; IN-VITRO; RAT ILEUM; CYCLOOXYGENASE-1; PROSTAGLANDINS; DYSFUNCTION; EXPOSURE; MOTILITY; JEJUNUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: MacNaughton, WK Univ Calgary, Mucosal Inflammat Res Grp, Calgary, AB T2N 1N4, Canada Univ Calgary Calgary AB Canada T2N 1N4 AB T2N 1N4, Canada
Citazione:
S.L. Freeman et al., "Radiation-induced acute intestinal inflammation differs following total-body versus abdominopelvic irradiation in the ferret", INT J RAD B, 77(3), 2001, pp. 389-395

Abstract

Purpose: The studies were designed to investigate the differences in the intestinal inflammatory response following abdominopelvic or total-body irradiation in a ferret model. Materials and methods: Ferrets were exposed either to total-body or to abdominopelvic gamma -radiation (5 Gy) and various parameters of inflammation studied in the jejunum, ileum and colon 2 and 7 days later. Results: Abdominopelvic and, to a greater extent, total-body irradiation caused weight loss by 7 days. White blood cell counts were reduced in both groups, but more so following total-body irradiation, Myeloperoxidase activity was significantly increased in the ileum 2 days after abdominopelvic irradiation, but it was reduced after total-body irradiation. Total-body irradiation increased tissue prostaglandin E-2 levels in all regions at 2 days and decreased jejunal leukotriene B-4 levels in the jejunum at both time points. Ileal prostaglandin E-2 levels were increased 2 days after abdominopelvic irradiation. Expression of inducible nitric oxide synthase was not altered by either irradiation protocol. Conclusions: The data show that there are regional differences in the intestinal response to irradiation, depending on whether it was delivered to the whole body or locally to the abdominopelvic region. In particular, the ileum exhibited an acute increase in myeloperoxidase activity following abdominopelvic but not total-body irradiation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 13:16:13