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Titolo:
The combination ace-inhibitors plus canreonate in patients with anterior myocardial infarction: safety and tolerability study
Autore:
Di Pasquale, P; Alessi, V; Barberi, O; Scandurra, A; Bucca, V; Maringhini, G; Scalzo, S; Paterna, S;
Indirizzi:
GF Ingrassia Hosp, Div Cardiol, Palermo, Italy GF Ingrassia Hosp PalermoItaly assia Hosp, Div Cardiol, Palermo, Italy Civic Hosp, Div Anesthesiol, Palermo, Italy Civic Hosp Palermo ItalyCivic Hosp, Div Anesthesiol, Palermo, Italy Univ Palermo, Dept Internal Med, Palermo, Italy Univ Palermo Palermo Italy v Palermo, Dept Internal Med, Palermo, Italy
Titolo Testata:
INTERNATIONAL JOURNAL OF CARDIOLOGY
fascicolo: 2-3, volume: 77, anno: 2001,
pagine: 119 - 127
SICI:
0167-5273(200102)77:2-3<119:TCAPCI>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANGIOTENSIN-CONVERTING ENZYME; CONGESTIVE-HEART-FAILURE; LEFT-VENTRICULAR DYSFUNCTION; ALDOSTERONE SYSTEM; HYPERTENSIVE RATS; CONTROLLED TRIAL; IN-VIVO; SPIRONOLACTONE; RENIN; BLOCKADE;
Keywords:
acute myocardial infarction; aldosterone; canreonate; E/A ratio;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Di Pasquale, P GF Ingrassia Hosp, Div Cardiol, Palermo, Italy GF IngrassiaHosp Palermo Italy Cardiol, Palermo, Italy
Citazione:
P. Di Pasquale et al., "The combination ace-inhibitors plus canreonate in patients with anterior myocardial infarction: safety and tolerability study", INT J CARD, 77(2-3), 2001, pp. 119-127

Abstract

Background: There is recent evidence that aldosterone (ALDO) exerts pro-fibrotic effects, acting via the mineral-corticoid receptors in cardiovascular tissues and partial aldosterone escape during ACE-inhibition treatment occurs. Methods: A double blind randomised study was performed to evaluate the feasibility, and tolerability of the administration of the 25 mg/day of canreonate plus captopril versus captopril alone in patients with anterior AMI unsuitable for thrombolysis and/or not receiving thrombolytic treatment,and unreperfused after thrombolysis. Fifty five patients hospitalised for anterior AMI,with a serum creatinine concentration <2.0 mg/dl and a serum Kconcentration <5.0 mmol per liter were randomised in 2 groups: Group A included 27 patients who received captopril and 25 mg i.v. of canreonate (1 mg/h for the 1st 72 h and then orally 25 mg/day. Group B (28 patients) received captopril and placebo. Ten days after admission they underwent echocardiography to determine end systolic volume (ESV), ejection fraction (EF), Enddiastolic diameter EDD, E/A ratio, E deceleration time (dec. time) and isovolumetric relaxation time (IVRT), E and A peak velocities. Results: All patients did not show patency of the infarct related artery (7-10 days after AMI) and the 2 groups were similar in regard to age, sex, diabetes, smokinghabits, hypertension, CK enzymatic peak, adjuvant therapy, EF, ESV, and incidence of CABG/PTCA. One patient only showed increase of serum K>5.5 mmol/dl and creatinine >2.0 mg per liter after 10 days of treatment (group A). The: mitral EIA ratio was higher in group A than group B (0.85 +/- 0.18 and 0.75 +/- 0.14) respectively, P = 0.024. Creatinine, blood urea and serum K did not show significant differences between groups. No side effects were observed during the study period. The incidence of vessel diseases was similar in both groups. Conclusions: Our data suggest that the combination of captopril plus canreonate in feasible in early treatment of AMI patients. (C)2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/10/20 alle ore 10:12:13