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Titolo:
Pericardial fluid as a new material for clinical heart research
Autore:
Fujita, M; Komeda, M; Hasegawa, K; Kihara, Y; Nohara, R; Sasayama, S;
Indirizzi:
Kyoto Univ, Coll Med Technol, Sakyo Ku, Kyoto 6068507, Japan Kyoto Univ Kyoto Japan 6068507 d Technol, Sakyo Ku, Kyoto 6068507, Japan Kyoto Univ, Dept Cardiovasc Surg, Sakyo Ku, Kyoto 6068507, Japan Kyoto Univ Kyoto Japan 6068507 vasc Surg, Sakyo Ku, Kyoto 6068507, Japan Kyoto Univ, Dept Cardiovasc Med, Sakyo Ku, Kyoto 6068507, Japan Kyoto Univ Kyoto Japan 6068507 ovasc Med, Sakyo Ku, Kyoto 6068507, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF CARDIOLOGY
fascicolo: 2-3, volume: 77, anno: 2001,
pagine: 113 - 118
SICI:
0167-5273(200102)77:2-3<113:PFAANM>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIBROBLAST-GROWTH-FACTOR; ACUTE MYOCARDIAL-INFARCTION; BRAIN NATRIURETIC PEPTIDE; UNSTABLE ANGINA; CARDIAC MYOCYTES; ELEVATED LEVELS; FAILURE; ISCHEMIA; DISEASE; ANGIOGENESIS;
Keywords:
angiogenesis; angiogenic growth factor; apoptosis; natriuretic peptide; pericardial fluid;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Fujita, M Kyoto Univ, Coll Med Technol, Sakyo Ku, 53 Kawaharacho, Kyoto 6068507, Japan Kyoto Univ 53 Kawaharacho Kyoto Japan 6068507 to 6068507, Japan
Citazione:
M. Fujita et al., "Pericardial fluid as a new material for clinical heart research", INT J CARD, 77(2-3), 2001, pp. 113-118

Abstract

This article will review the results of recent clinical studies relating to the pericardial fluid in patients with various heart diseases. In ischemic patients, several angiogenic growth factors are accumulated in a high concentration in pericardial fluid. These may contribute to the angiogenesis and arteriogenesis, which are self-protecting mechanisms of myocardial ischemia. In congestive heart failure, natriuretic peptides are released into the pericardial fluid in a higher concentration compared with plasma levels. This suggests that these peptides may act as autocrine and/or paracrine factors. Pericardial fluid from ischemic patients induces cell proliferation and apoptosis depending on the cell type. Intrapericardial drug administration may provide a reasonable therapeutic strategy for heart diseases. In conclusion, the analysis of pericardial fluid appears to be a logical approachfor elucidation of the pathophysiology of the heart. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/05/20 alle ore 14:52:14