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Titolo:
Innate immune response of Aedes aegypti
Autore:
Lowenberger, C;
Indirizzi:
Univ Wisconsin, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706Univ Wisconsin, Madison, WI 53706 USA
Titolo Testata:
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
fascicolo: 3, volume: 31, anno: 2001,
pagine: 219 - 229
SICI:
0965-1748(20010301)31:3<219:IIROAA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
RICH ANTIMICROBIAL PEPTIDES; MOSQUITO ANOPHELES-GAMBIAE; FLIGHT MASS-SPECTROMETRY; ANTIBACTERIAL PEPTIDE; INSECT IMMUNITY; MOLECULAR-CLONING; SPOROGONIC DEVELOPMENT; VECTOR MOSQUITO; PLASMODIUM-BERGHEI; DEFENSIN-A;
Keywords:
Aedes aegypti; innate immunity; defensin; cecropin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
85
Recensione:
Indirizzi per estratti:
Indirizzo: Lowenberger, C Univ Wisconsin, 1656 Linden Dr, Madison, WI 53706 USA Univ Wisconsin 1656 Linden Dr Madison WI USA 53706 3706 USA
Citazione:
C. Lowenberger, "Innate immune response of Aedes aegypti", INSEC BIO M, 31(3), 2001, pp. 219-229

Abstract

Insects are able to protect themselves from invasion by pathogens by a rapid and potent arsenal of inducible immune peptides. This fast, extremely effective response is part of the innate immunity exhibited by all insects and many invertebrates, and shows striking similarities with the innate immune response of vertebrates. In Aedes aegypti invasion of the hemocoel by bacteria elicits the production of defensins, cecropins, a peptide active onlyagainst Gram-negative bacteria, and several other peptides that we are nowcharacterizing. However, not all insects utilize the same peptides in the same concentrations, which may reflect the pathogens to which they may havebeen exposed through evolutionary time. These protective measures we see in mosquitoes are the current state of the evolution of a rapid immune response that has contributed to the success of insects in inhabiting essentially every niche on earth. The molecules involved in the response of Aedes aegypti to pathogens, and the potential role of these peptides against eukaryotic parasites ingested and transmitted by mosquitoes are discussed. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 13:41:26