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Titolo:
Pleiotropic effects of corticotropin releasing hormone on normal human skin keratinocytes
Autore:
Quevedo, ME; Slominski, A; Pinto, W; Wei, E; Wortsman, J;
Indirizzi:
Univ Tennessee, Dept Pathol, Memphis, TN 38163 USA Univ Tennessee MemphisTN USA 38163 e, Dept Pathol, Memphis, TN 38163 USA Loyola Univ, Med Ctr, Dept Pathol, Maywood, IL 60153 USA Loyola Univ Maywood IL USA 60153 Ctr, Dept Pathol, Maywood, IL 60153 USA Univ Calif Berkeley, Sch Publ Hlth, Berkeley, CA 94708 USA Univ Calif Berkeley Berkeley CA USA 94708 bl Hlth, Berkeley, CA 94708 USA So Illinois Univ, Dept Med, Springfield, IL 62794 USA So Illinois Univ Springfield IL USA 62794 Med, Springfield, IL 62794 USA
Titolo Testata:
IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
fascicolo: 1, volume: 37, anno: 2001,
pagine: 50 - 54
SICI:
1071-2690(200101)37:1<50:PEOCRH>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
RODENT MELANOMA-CELLS; INFLAMMATORY ARTHRITIS; EXPRESSION; SECRETION; STRESS; PROOPIOMELANOCORTIN; MECHANISM; RECEPTORS; PEPTIDES; CRF;
Keywords:
corticotropin releasing hormone (CRH); CRH receptor type 1; keratinocytes; human skin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Slominski, A Univ Tennessee, Dept Pathol, RM576-BMH Main,899 Madison Ave, Memphis, TN 38163 USA Univ Tennessee RM576-BMH Main,899 Madison Ave MemphisTN USA 38163
Citazione:
M.E. Quevedo et al., "Pleiotropic effects of corticotropin releasing hormone on normal human skin keratinocytes", IN VITRO-AN, 37(1), 2001, pp. 50-54

Abstract

The hypothalamic-pituitary-adrenal (HPA) axis is the major stress responsesystem. Several components of the HPA axis, such as corticotropin-releasing hormone (CRH) and POMC peptides and their receptors are also present in the skin. In earlier studies, we showed that CRH inhibits cellular proliferation of immortalized human keratinocytes, We now examine further the functional activity of the HPA axis in the skin, by characterizing the actions ofCRH on normal foreskin keratinocytes. The CRH receptor was detected as CRH-R1 antigen at 47 kDa in the cultured keratinocytes by Western blotting, and immunohistochemistry demonstrated its presence in the epidermal and follicular keratinocytes. CRH is also biologically active in cultured keratinocytes, where it inhibits proliferation and enhances the interferon-gamma -stimulated expression of the hCAaM and ICAM-1 adhesion molecules and of the HLA-DR antigen, These effects were concentration-dependent, with maximal activity at CRH 10(-7) M. Thus. in the keratinocyte, the most important cellular component of the epidermis, CRH appears to induce a shift in energy metabolism away from proliferation activity, and toward the enhancement of immunoactivity. Therefore, similar to its central actions. cutaneous CRH may also be involved in the stress response, but at a highly localized level.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 19:27:10