Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Mitochondria: potential roles in embryogenesis and nucleocytoplasmic transfer
Autore:
Cummins, JM;
Indirizzi:
Murdoch Univ, Div Vet & Biomed Sci, Perth, WA 6849, Australia Murdoch Univ Perth WA Australia 6849 iomed Sci, Perth, WA 6849, Australia
Titolo Testata:
HUMAN REPRODUCTION UPDATE
fascicolo: 2, volume: 7, anno: 2001,
pagine: 217 - 228
SICI:
1355-4786(200103/04)7:2<217:MPRIEA>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
PREIMPLANTATION EMBRYO DEVELOPMENT; INTRACYTOPLASMIC SPERM INJECTION; CYTOCHROME-C-OXIDASE; HUMAN NUCLEAR GENOME; HUMAN OOCYTES; IN-VITRO; BOVINE EMBRYOS; MUTANT MTDNA; CELL-DEATH; GENOTYPE SEGREGATION;
Keywords:
ageing; apoptosis; cloning; cytoplasmic transfer; mitochondrial DNA;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
236
Recensione:
Indirizzi per estratti:
Indirizzo: Cummins, JM Murdoch Univ, Div Vet & Biomed Sci, GPO Box S1400, Perth, WA 6849, Australia Murdoch Univ GPO Box S1400 Perth WA Australia 6849 , Australia
Citazione:
J.M. Cummins, "Mitochondria: potential roles in embryogenesis and nucleocytoplasmic transfer", HUM REP UPD, 7(2), 2001, pp. 217-228

Abstract

This review examines current understanding of mammalian mitochondria and mitochondrial DNA in the light of new reproductive technologies. Mitochondria are central to ageing, apoptosis, metabolism and many diseases. They are controlled by a dual genome system, with cooperation between endogenous mitochondrial genes and mitochondrial genes translocated to the nucleus over the course of evolution. This translocation has been accompanied by extreme compression of the mitochondrial genome, with little tolerance for mutations or heteroplasmy (multiple genomes). The highly compact mitochondrial genome appears to be maintained by a stringent numerical bottleneck in embryogenesis and oogenesis, followed by clonal expansion from a highly selected subset of precursor molecules. The dual nature of control between nucleus andcytoplasm sets up potential conflicts, which are normally resolved by natural selection, Such potentially opposing interests and mechanisms are probably partly to blame for the poor rates of success in cloning animals by nuclear transfer. The ability to construct cell systems and animal embryos with novel combinations and permutations of nuclear and cytoplasmic genes willprovide powerful tools for examining these fundamental biological questions. Clinically, attempts to 'rescue' abnormal human oocytes or embryos by cytoplasmic transfer risk complex and unpredictable outcomes emerging from disharmonious nuclear-cytoplasmic interactions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 14:41:56