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Titolo:
Oxidative stress and protection against reactive oxygen species in the pre-implantation embryo and its surroundings
Autore:
Guerin, P; El Mouatassim, S; Menezo, Y;
Indirizzi:
Ecole Natl Vet Lyon, Unite Biol Reprod, F-69280 Marcy Etoile, France EcoleNatl Vet Lyon Marcy Etoile France F-69280 280 Marcy Etoile, France Lab Marcel Merieux, F-69357 Lyon, France Lab Marcel Merieux Lyon France F-69357 cel Merieux, F-69357 Lyon, France Univ Lyon 1, Fac Med, F-69373 Lyon, France Univ Lyon 1 Lyon France F-69373 iv Lyon 1, Fac Med, F-69373 Lyon, France
Titolo Testata:
HUMAN REPRODUCTION UPDATE
fascicolo: 2, volume: 7, anno: 2001,
pagine: 175 - 189
SICI:
1355-4786(200103/04)7:2<175:OSAPAR>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
PREIMPLANTATION MOUSE EMBRYOS; ENCODING ANTIOXIDANT ENZYMES; IN-VITRO FERTILIZATION; PROTEIN-FREE MEDIUM; BOVINE EMBRYOS; HUMAN SPERMATOZOA; SUPEROXIDE-DISMUTASE; HYDROGEN-PEROXIDE; HUMAN SPERM; VITAMIN-E;
Keywords:
antioxidant enzymes; embryo culture; non-enzymatic antioxidant defences; oocyte; reactive oxygen species;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
134
Recensione:
Indirizzi per estratti:
Indirizzo: Guerin, P Ecole Natl Vet Lyon, Unite Biol Reprod, BP 83, F-69280 Marcy Etoile, France Ecole Natl Vet Lyon BP 83 Marcy Etoile France F-69280 e, France
Citazione:
P. Guerin et al., "Oxidative stress and protection against reactive oxygen species in the pre-implantation embryo and its surroundings", HUM REP UPD, 7(2), 2001, pp. 175-189

Abstract

Oxidative stress is involved in the aetiology of defective embryo development. Reactive oxygen species (ROS) may originate from embryo metabolism and/or embryo surroundings. Embryo metabolism generates ROS via several enzymatic mechanisms. The relative contribution of each source seems different depending on the species, the stage of development, and the culture conditions. Several exogenous factors and culture conditions can enhance the production of ROS by embryos. ROS can alter most types of cellular molecules, and also induce development block and retardation. Multiple mechanisms of embryo protection against ROS exist, and these have complementary actions. External protection, present in follicular and tubal fluids, mainly comprises non-enzymatic antioxidants such as hypotaurine, taurine and ascorbic acid, Internal protection mainly comprises antioxidant enzymes: superoxide dismutase, glutathione peroxidase and gamma -glutamylcysteine synthetase. Transcripts encoding for these enzymes are present in the oocyte, embryo and oviduct. It may be important that these transcripts are stored during oocyte maturation in order to allow the embryo to acquire the aptitude to develop. It is now common to add antioxidant compounds to culture media. Nevertheless, maintaining the pro-oxidant-antioxidant equilibrium in embryos through such supplementation is a complex problem. Further studies are necessary to limit oxidative stress during embryo culture.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 03:37:25