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Titolo:
Human reproductive failure II: Immunogenetic and interacting factors
Autore:
Choudhury, SR; Knapp, LA;
Indirizzi:
Univ Cambridge, Dept Biol Anthropol, Cambridge CB2 3DZ, England Univ Cambridge Cambridge England CB2 3DZ pol, Cambridge CB2 3DZ, England
Titolo Testata:
HUMAN REPRODUCTION UPDATE
fascicolo: 2, volume: 7, anno: 2001,
pagine: 135 - 160
SICI:
1355-4786(200103/04)7:2<135:HRFIIA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAJOR HISTOCOMPATIBILITY COMPLEX; MHC-CLASS-I; NATURAL-KILLER-CELLS; RECURRENT SPONTANEOUS-ABORTION; HLA-G EXPRESSION; LEUKEMIA-INHIBITORY FACTOR; HUMAN-LEUKOCYTE ANTIGENS; EARLY-PREGNANCY DECIDUA; TUMOR-NECROSIS-FACTOR; G MESSENGER-RNA;
Keywords:
early pregnancy loss; HLA; pregnancy; recurrent spontaneous abortion; reproductive failure;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
418
Recensione:
Indirizzi per estratti:
Indirizzo: Knapp, LA Univ Cambridge, Dept Biol Anthropol, Downing St, Cambridge CB2 3DZ, England Univ Cambridge Downing St Cambridge England CB2 3DZ DZ, England
Citazione:
S.R. Choudhury e L.A. Knapp, "Human reproductive failure II: Immunogenetic and interacting factors", HUM REP UPD, 7(2), 2001, pp. 135-160

Abstract

Studies in humans suggest that reproductive failure may be influenced by immunological factors or by genes encoding immunological factors and regulatory mechanisms controlling immunological expression. Using molecular methods, immunological factors can be dearly studied in an immunogenetic context. One example, the major histocompatibility complex (MHC), known as the human leukocyte antigens (HLA) in humans and MHC in other mammals, affects manydifferent stages of reproduction. Studies in some outbred, and in closely related, human populations indicate that HLA, or HLA-linked, genes and HLA regulatory factors affect gamete development, embryo cleavage, blastocyst and trophoblast formation, implantation, fetal development and survival. Studies in nonhuman mammals indicate that MHC, or MHC-linked, genes such as the grc complex, Ped/Qa-2, t haplotypes and MHC regulatory factors, have similar reproductive effects. Human reproductive failure may also be a consequence of disruption of interacting factors, including interactions between HLA antigens, cytokines and natural killer (NK) cells. In this review, we highlight the importance of immunogenetic and interacting factors in human reproductive failure. We argue that studies in closely related human populations and animal models may contribute to a better understanding of the ways in which immunogenetic and interacting factors are involved in human reproduction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 08:05:43