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Titolo:
Stress and hippocampal plasticity: implications for the pathophysiology ofaffective disorders
Autore:
McEwen, BS; Magarinos, AM;
Indirizzi:
Rockefeller Univ, Harold & Margaret Milliken HatchLab Neuroendocrin, New York, NY 10021 USA Rockefeller Univ New York NY USA 10021 roendocrin, New York, NY 10021 USA
Titolo Testata:
HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
, volume: 16, anno: 2001, supplemento:, 1
pagine: S7 - S19
SICI:
0885-6222(200101)16:<S7:SAHPIF>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; METHYL-D-ASPARTATE; RECURRENT MAJOR DEPRESSION; CA3 PYRAMIDAL NEURONS; MESSENGER-RNA LEVELS; PITUITARY-ADRENOCORTICAL AXIS; SUBGENUAL PREFRONTAL CORTEX; PRIMED BURST POTENTIATION; ADRENAL-STEROID RECEPTORS; DENDRITIC SPINE DENSITY;
Keywords:
hippocampus; depression; tianeptine; stress; serotonin; excitatory amino acids;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
120
Recensione:
Indirizzi per estratti:
Indirizzo: McEwen, BS Rockefeller Univ, Harold & Margaret Milliken HatchLab Neuroendocrin, 1230 York Ave,Box 165, New York, NY 10021 USA Rockefeller Univ 1230 York Ave,Box 165 New York NY USA 10021 SA
Citazione:
B.S. McEwen e A.M. Magarinos, "Stress and hippocampal plasticity: implications for the pathophysiology ofaffective disorders", HUM PSYCHOP, 16, 2001, pp. S7-S19

Abstract

The hippocampal formation, a structure involved in declarative, spatial and contextual memory, is a particularly sensitive and vulnerable brain region to stress and stress hormones. The hippocampus shows a considerable degree of structural plasticity in the adult brain. Stress suppresses neurogenesis of dentate gyrus granule neurons, and repeated stress causes atrophy of dendrites in the CA3 region. In addition, ovarian steroids regulate synapseformation during the estrous cycle of female rats. All three forms of structural remodeling of the hippocampus are mediated by hormones working in concert with excitatory amino acids (EAA) and N-methyl-D-aspartate (NMDA) receptors. EAA and NMDA receptors are also involved in neuronal death that is caused in pyramidal neurons by seizures and by ischemia and prolonged psychosocial stress. In the human hippocampus, magnetic resonance imaging studies have shown that there is a selective atrophy in recurrent depressive illness, accompanied by deficits in memory performance. Hippocampal atrophy maybe a feature of affective disorders that is not treated by all medications. From a therapeutic standpoint, it is essential to distinguish between permanent damage and reversible atrophy in order to develop treatment strategies to either prevent or reverse deficits. In addition, remodeling of brain cells may occur in other brain regions. Possible treatments are discussed. Copyright (C) 2001 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 07:07:45