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Titolo:
Categorical default uncertainty factors - Interspecies variation and adequacy of database
Autore:
Meek, ME;
Indirizzi:
Hlth Canada, Ctr Environm Hlth, Ottawa, ON K1A 0L2, Canada Hlth Canada Ottawa ON Canada K1A 0L2 onm Hlth, Ottawa, ON K1A 0L2, Canada
Titolo Testata:
HUMAN AND ECOLOGICAL RISK ASSESSMENT
fascicolo: 1, volume: 7, anno: 2001,
pagine: 157 - 163
SICI:
1080-7039(200102)7:1<157:CDUF-I>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONCANCER;
Keywords:
uncertainty; variability; tolerable or reference dose/concentration; interspecies variation; body surface area scaling; adequacy of database; categorical default;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Meek, ME Hlth Canada, Ctr Environm Hlth, Tunneys Pasture,0801C2, Ottawa, ON K1A 0L2, Canada Hlth Canada Tunneys Pasture,0801C2 Ottawa ON Canada K1A 0L2 anada
Citazione:
M.E. Meek, "Categorical default uncertainty factors - Interspecies variation and adequacy of database", HUM ECOL R, 7(1), 2001, pp. 157-163

Abstract

The potential application of categorical (i.e., species, pathway, or groupspecific) defaults for several components of uncertainty relevant to development of tolerable or reference concentrations/doses is considered-namely,interspecies variation and adequacy of database. For the former, the adequacy of allometric scaling by body surface area as a species-specific default for oral tolerable or reference doses is considered. For the latter, the extent to which data from analyses of subchronic:chronic effect levels, LOAELs/NOAELs, and critical effect levels for complete versus incomplete datasets informs selection of defaults is examined. The relative role of categorical defaults for these aspects is considered in the context of the continuum of increasingly data-informed approaches to characterization of uncertainty and variability that range from default ("presumed protective") to "biologically based predictive".

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 23:22:57