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Titolo:
Neurotrophic and migratory properties of an olfactory ensheathing cell line
Autore:
Boruch, AV; Conners, JJ; Pipitone, M; Deadwyler, G; Storer, PD; Devries, GH; Jones, KJ;
Indirizzi:
Loyola Univ, Stritch Sch Med, Dept Cell Biol Neurobiol & Anat, Maywood, IL60153 USA Loyola Univ Maywood IL USA 60153 l Neurobiol & Anat, Maywood, IL60153 USA Hines VA Hosp, Hines, IL USA Hines VA Hosp Hines IL USAHines VA Hosp, Hines, IL USA
Titolo Testata:
GLIA
fascicolo: 3, volume: 33, anno: 2001,
pagine: 225 - 229
SICI:
0894-1491(20010301)33:3<225:NAMPOA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT SPINAL-CORD; NERVE GROWTH-FACTOR; NEURON REGENERATION; CORTICOSPINAL TRACT; GLIA TRANSPLANTS; AXONAL GROWTH; SYSTEM; DIFFERENTIATION; PROLIFERATION; NEUROGENESIS;
Keywords:
ensheathing glia; neurotrophins; spinal cord injury; regeneration; xenograft;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Jones, KJ Loyola Univ, Stritch Sch Med, Dept Cell Biol Neurobiol & Anat, 2160 S 1st Ave, Maywood, IL 60153 USA Loyola Univ 2160 S 1st Ave Maywood IL USA 60153 od, IL 60153 USA
Citazione:
A.V. Boruch et al., "Neurotrophic and migratory properties of an olfactory ensheathing cell line", GLIA, 33(3), 2001, pp. 225-229

Abstract

Olfactory ensheathing cells (OECs) are a unique type of macroglia requiredfor normal olfactory axonal regeneration throughout the lifetime of an individual. Recent evidence in the literature suggests that OECs transplanted into injured spinal cords may facilitate axonal regeneration. In this study, we evaluated the neurotrophic properties of OECs using a homogeneous clonal cell line (nOEC), which does not contain contaminating cell types found in all primary OEC cultures. The results indicate that nOECs express mRNA for NGF, BDNF, NT-4/5, and neuregulins, but not for NT-3 or CNTF. In addition, nOECs secrete NGF, BDNF, and neuregulin, but retain NT-4/5 intracellularly. Finally, prelabeled nOECs derived from rat survived transplantation into a dorsal hemisected region of the hamster spinal cord and migrated only in the injured, dorsal portion of the spinal cord. This migratory pattern suggests that the nOECs are viable in vivo and respond to signals originatingfrom the injured neuronal cells and their processes. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 15:05:07