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Titolo:
Sequence diversity of Vipera lebetina snake venom,oland serine proteinase homologs - result of alternative-splicing or genome alteration
Autore:
Siigur, E; Aaspollu, A; Siigur, J;
Indirizzi:
Natl Inst Chem Phys & Biophys, EE-12618 Tallinn, Estonia Natl Inst Chem Phys & Biophys Tallinn Estonia EE-12618 Tallinn, Estonia
Titolo Testata:
GENE
fascicolo: 1-2, volume: 263, anno: 2001,
pagine: 199 - 203
SICI:
0378-1119(20010124)263:1-2<199:SDOVLS>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMINO-ACID-SEQUENCE; V-ACTIVATING ENZYME; MOLECULAR-CLONING; VENOM ENZYME; CDNA; PURIFICATION; GENE; IDENTIFICATION; BATROXOBIN; EXON;
Keywords:
snake venom; serine proteinases; cDNA cloning; trans-splicing; exon shuffling; Vipera lebetina;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Siigur, J Natl Inst Chem Phys & Biophys, Akadeemia Tee 23, EE-12618 Tallinn, Estonia Natl Inst Chem Phys & Biophys Akadeemia Tee 23 Tallinn Estonia EE-12618
Citazione:
E. Siigur et al., "Sequence diversity of Vipera lebetina snake venom,oland serine proteinase homologs - result of alternative-splicing or genome alteration", GENE, 263(1-2), 2001, pp. 199-203

Abstract

Four clones encoding homologous protein(ase)s were isolated from the Vipera lebetina (snake) venom,oland cDNA library. One of them represented DNA encoding factor V activating enzyme (Siigur et al., 1999), the other is homologous to VLFVA but has two principal discrepancies in the translated protein sequence in comparison with snake venom serine proteinase structures: in the active site triad Ser195 is replaced by Asn195 and His57 by Arg57. The third and the fourth clone represent combinations of the first two clones. The possibilities of generation of such clones via trans-splicing of the primary gene transcript, by exon shuffling or by unequal crossing-over on thegenome level are discussed. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 12/07/20 alle ore 04:36:51