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Titolo:
Where do Alzheimer's plaques and tangles come from? Aging-induced protein degradation inefficiency
Autore:
Chen, M; Fernandez, HL;
Indirizzi:
Bay Pines VA Med Ctr, Med Res Serv 151, Neurosci Res Lab, Bay Pines, FL 33744 USA Bay Pines VA Med Ctr Bay Pines FL USA 33744 Lab, Bay Pines, FL 33744 USA Univ S Florida, Coll Med, Dept Pharmacol & Therapeut, Tampa, FL 33612 USA Univ S Florida Tampa FL USA 33612 rmacol & Therapeut, Tampa, FL 33612 USA Univ S Florida, Coll Med, Dept Neurol, Tampa, FL 33612 USA Univ S FloridaTampa FL USA 33612 l Med, Dept Neurol, Tampa, FL 33612 USA Univ S Florida, Coll Med, Dept Physiol & Biophys, Tampa, FL 33612 USA UnivS Florida Tampa FL USA 33612 Physiol & Biophys, Tampa, FL 33612 USA
Titolo Testata:
FRONTIERS IN BIOSCIENCE
, volume: 6, anno: 2001,
pagine: E1 - E11
SICI:
1093-9946(200103)6:<E1:WDAPAT>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYLOID PRECURSOR PROTEIN; CALCIUM-DEPENDENT PROTEASE; ALPHA-SECRETASE CLEAVAGE; TRANS-GOLGI NETWORK; BETA-SECRETASE; KINASE-C; NEURODEGENERATIVE DISEASES; HUMAN PLATELETS; HUMAN-TAU; CALPAIN;
Keywords:
aging; Alzheimer disease; amyloid; tau; calcium; calpain; atherosclerosis; review;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
90
Recensione:
Indirizzi per estratti:
Indirizzo: Chen, M Bay Pines VA Med Ctr, Med Res Serv 151, Neurosci Res Lab, Bay Pines, FL 33744 USA Bay Pines VA Med Ctr Bay Pines FL USA 33744 y Pines, FL 33744 USA
Citazione:
M. Chen e H.L. Fernandez, "Where do Alzheimer's plaques and tangles come from? Aging-induced protein degradation inefficiency", FRONT BIOSC, 6, 2001, pp. E1-E11

Abstract

Amyloid plaques and neurofibrillary tangles are prominent lesions in the aging brain and they may be responsible for cell death in Alzheimer's disease. But a basic question has not been answered: why and how are plaques and tangles formed during aging? In this study, we approach this question by first examining what happens in the aging body. Plaques and tangles do not come alone, but together with many other aging markers in the body (cholesterol deposition, gallstones, hair graying, and bone loss, etc.). Because these aging markers occur to a certain extent in all elderly and at about the same time in life, it is reasonable to conceive that they originate from a common cause, that is, aging-induced metabolic inefficiency. If cholesterol and gallstone depositions are the results of inefficient degradation/clearance of lipids and minerals, then similarly plaque and tangle formation in most people would be the results of inefficient normal degradation of beta -amyloid precursor protein (APP) and tau, respectively. By this view, our studies should focus on the enzymes responsible for APP and tau normal degradation and their natural changes in aging, rather than on presumed pathological factors. Whatever precise mechanisms underlying their depositions, plaques and tangles are the natural products of aging, thus fundamentally different from pathological events such as cancer growth in concept.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 12:46:02