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Titolo:
Cd8(+) T cell mediated noncytolytic inhibition of human immunodeficiency virus type I
Autore:
Tomaras, GD; Greenberg, ML;
Indirizzi:
Duke Univ, Med Ctr, Dept Surg, Ctr AIDS Res, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 pt Surg, Ctr AIDS Res, Durham, NC 27710 USA
Titolo Testata:
FRONTIERS IN BIOSCIENCE
, volume: 6, anno: 2001,
pagine: D575 - D598
SICI:
1093-9946(200103)6:<D575:CTCMNI>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG TERMINAL REPEAT; ANTI-HIV ACTIVITY; DRIVEN GENE-EXPRESSION; TOXIC LYMPHOCYTES-T; PERIPHERAL-BLOOD LYMPHOCYTES; BETA-CHEMOKINES RANTES; NECROSIS-FACTOR-ALPHA; INFECTED CD4+ CELLS; C-C CHEMOKINES; CD8+ LYMPHOCYTES;
Keywords:
CD8(+) T cell; noncytolytic; human immunodeficiency virus (HIV); HIV-LTR; simian immunodeficiency virus (SIV); pathogenesis; vaccines; antiviral; review;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
172
Recensione:
Indirizzi per estratti:
Indirizzo: Tomaras, GD Duke Univ, Med Ctr, Dept Surg, Ctr AIDS Res, Box 2926 SORF La Salle St Ext, Durham, NC 27710 USA Duke Univ Box 2926 SORF La Salle St Ext Durham NC USA 27710 SA
Citazione:
G.D. Tomaras e M.L. Greenberg, "Cd8(+) T cell mediated noncytolytic inhibition of human immunodeficiency virus type I", FRONT BIOSC, 6, 2001, pp. D575-D598

Abstract

The development of cellular immune responses in primary human immunodeficiency virus type-1 (HIV-1) infection is accompanied by a dramatic decrease in plasma viremia and resolution of the acute clinical syndrome. The full nature of the immunological response and its consequences on HIV pathogenesisis still largely a mystery, but significant progress has been achieved in the characterization of some of the players involved. Several studies indicate that noncytolytic HIV suppression by CD8(+) T lymphocytes may be inversely associated with viral loadTable 1. Characteristics of CD8(+) Antiviral ActivityNon-cytolytic inhibition of virus replicationNot HLA restricted, but some enhancement is seenwhen matchedDose dependentEffective against acutely or endogenously infected CD4(+) T-cellsDeclines with progression to AIDSSoluble and Contact mediatedEffective against CCR5 and CXCR4 utilizing virusesPresent in some exposed uninfected individualssuggesting that this antiviral activity is important in host control of HIV replication. This review focuses on this antiviral activity by CD8(+) T lymphocytes, which is distinct from that activity elicited by some cytolyticCD8(+) T lymphocytes (CTLs).

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Documento generato il 01/12/20 alle ore 01:09:11