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Titolo:
Apolipoprotein(a): Structure and biology
Autore:
Scanu, AM; Nakajima, K; Edelstein, C;
Indirizzi:
Univ Chicago, Dept Med, Chicago, IL 60637 USA Univ Chicago Chicago IL USA60637 hicago, Dept Med, Chicago, IL 60637 USA Univ Chicago, Dept Biochem & Mol Biol, Chicago, IL 60637 USA Univ ChicagoChicago IL USA 60637 ochem & Mol Biol, Chicago, IL 60637 USA
Titolo Testata:
FRONTIERS IN BIOSCIENCE
, volume: 6, anno: 2001,
pagine: D546 - D554
SICI:
1093-9946(200103)6:<D546:ASAB>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; RHESUS-MONKEY LIPOPROTEIN(A); CORONARY-ARTERY DISEASE; LYSINE-BINDING-SITES; C-TERMINAL DOMAIN; POTENTIAL RELEVANCE; APO(A) FRAGMENTS; TRANSGENIC MICE; RENAL-FAILURE; PROTEIN CORE;
Keywords:
Lp(a); bound; unbound apo(a); apo(a); size; sequence; polymorphism; atherogenesis; review;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Scanu, AM Univ Chicago, Dept Med, MC5041,5841 S Maryland Ave, Chicago, IL 60637 USA Univ Chicago MC5041,5841 S Maryland Ave Chicago IL USA 60637 USA
Citazione:
A.M. Scanu et al., "Apolipoprotein(a): Structure and biology", FRONT BIOSC, 6, 2001, pp. D546-D554

Abstract

Apolipoprotein(a), apo(a), the distinctive glycoprotein constituent of lipoprotein(a), Lp(a), is synthesized in the liver, links covalently to apoB100-lipoprotein, and travels so linked in the plasma to tissue sites where removal mechanisms are yet undetermined. Depending on the redox status of thesurrounding milieu, apo(a) may re-acquire its unbound state shown to have structural and functional properties different from those of the bound form. Apo(a) is potentially atherothrombogenic, a property which may be influenced by its size, sequence polymorphism, type of lipoprotein it is linked toand the inflammatory state of the vessel wall. This set of variables must be taken into account when assessing the cardiovascular pathogenicity of free and bound apo(a).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 10:39:23