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Titolo:
Mouse models of hyperlipidemia and atherosclerosis
Autore:
Fazio, S; Linton, MF;
Indirizzi:
Vanderbilt Univ, Sch Med, Dept Med, Div Cardiovasc Med, Nashville, TN 37232 USA Vanderbilt Univ Nashville TN USA 37232 ovasc Med, Nashville, TN 37232 USA
Titolo Testata:
FRONTIERS IN BIOSCIENCE
, volume: 6, anno: 2001,
pagine: D515 - D525
SICI:
1093-9946(200103)6:<D515:MMOHAA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
DENSITY-LIPOPROTEIN RECEPTOR; E-DEFICIENT MICE; DIET-INDUCED ATHEROSCLEROSIS; BONE-MARROW TRANSPLANTATION; HUMAN APOLIPOPROTEIN-E; B MESSENGER-RNA; BINDING CASSETTE TRANSPORTER-1; MACROPHAGE SCAVENGER RECEPTORS; CORONARY HEART-DISEASE; ESTER TRANSFER PROTEIN;
Keywords:
cholesterol; mouse models; dyslipidemia; bone marrow transplantation; apolipoproteins; dietary fats; macrophages; atherosclerosis; review;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
96
Recensione:
Indirizzi per estratti:
Indirizzo: Fazio, S Vanderbilt Univ, Sch Med, Dept Med, Div Cardiovasc Med, 315 Med Res Bldg 2, Nashville, TN 37232 USA Vanderbilt Univ 315 Med Res Bldg 2 Nashville TN USA 37232 232 USA
Citazione:
S. Fazio e M.F. Linton, "Mouse models of hyperlipidemia and atherosclerosis", FRONT BIOSC, 6, 2001, pp. D515-D525

Abstract

The mouse is the most utilized model to study lipids and atherosclerosis. Before the advent of the techniques of genetic manipulation it was well known that different inbred strains had varying degrees of susceptibility to diet-induced atherosclerosis. The C57BL/6 mouse was adopted as the standard even though the arterial lesions induced by even extreme diets were limitedin size, complexity, and distribution. This changed with the production ofseveral gene knockout and transgenic mice, which in many cases produced remarkable effects on plasma lipoproteins and arterial lesions even without dietary manipulations. The most typical example remains the apoE deficient model, in which a massive hyperlipidemia is accompanied with the developmentof severe atherosclerotic plaques at the aortic root and throughout the aortic tree. With the creation of the LDL receptor knockout, and the different knockout and transgenic mice with changes in apoB, apoE, and the HDL system, a solid body of new information has emerged on the mechanisms regulating plasma lipoprotein levels and controlling the initial stages of atherogenesis. This paper presents an overview of the most utilized mouse models anda summary of the results obtained with the technique of bone marrow transplantation, an approach to study macrophages in atherosclerosis.

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Documento generato il 04/04/20 alle ore 23:31:46