Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Macrophage foam cells and atherosclerosis
Autore:
Kruth, HS;
Indirizzi:
NHLBI, Sect Expt Atherosclerosis, NIH, Bethesda, MD 20892 USA NHLBI Bethesda MD USA 20892 Atherosclerosis, NIH, Bethesda, MD 20892 USA
Titolo Testata:
FRONTIERS IN BIOSCIENCE
, volume: 6, anno: 2001,
pagine: D429 - D455
SICI:
1093-9946(200103)6:<D429:MFCAA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; MONOCYTE-DERIVED MACROPHAGES; MOUSE PERITONEAL-MACROPHAGES; CHOLESTERYL ESTER ACCUMULATION; TRIGLYCERIDE-RICH LIPOPROTEINS; ACYL-COENZYME-A; RECEPTOR-RELATED PROTEIN; SMOOTH-MUSCLE CELLS; INTRACELLULAR LIPID-ACCUMULATION; SURFACE-CONNECTED COMPARTMENTS;
Keywords:
atherosclerosis; cholesterol; lipoproteins; macrophage; vessels; lipids; metabolism; review;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
338
Recensione:
Indirizzi per estratti:
Indirizzo: Kruth, HS NHLBI, Sect Expt Atherosclerosis, NIH, Bldg 10,Room 5N-113,10 Ctr Dr MSC 1422, Bethesda, MD 20892 USA NHLBI Bldg 10,Room 5N-113,10 Ctr Dr MSC 1422 Bethesda MD USA 20892
Citazione:
H.S. Kruth, "Macrophage foam cells and atherosclerosis", FRONT BIOSC, 6, 2001, pp. D429-D455

Abstract

Focal buildup of cholesterol in arteries is the process that produces atherosclerotic plaques, the cause of most coronary artery disease and strokes. Monocyte-derived macrophages are central cells that accumulate this cholesterol in atherosclerotic lesions, a manifestation of the scavenging function of the macrophage. Different types of cholesterol-containing lipid particles found in atherosclerotic lesions may enter macrophages by a variety of endocytic pathways. The fate of cholesterol that enters macrophages determines whether macrophages help or hinder cholesterol removal from the vessel wall. Macrophages may function to carry cholesterol out of lesions, or to process the cholesterol for excretion in association with small protein-phospholipid complexes. Alternatively, macrophages that do not efficiently function to remove cholesterol from lesions may ultimately undergo cell death. Some cytokines, hormones, and pharmacologic agents show potential to modulate these processes and may be useful in directing macrophage function in atherosclerotic lesions towards beneficial rather than harmful effects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 16:32:14