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Titolo:
Postprandial lipoproteins and atherosclerosis
Autore:
Yu, KCW; Cooper, AD;
Indirizzi:
Palo Alto Med Fdn, Res Inst, Palo Alto, CA 94301 USA Palo Alto Med Fdn Palo Alto CA USA 94301 es Inst, Palo Alto, CA 94301 USA Stanford Univ, Med Ctr, Dept Med, Div Gastroenterol, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 Gastroenterol, Stanford, CA 94305 USA
Titolo Testata:
FRONTIERS IN BIOSCIENCE
, volume: 6, anno: 2001,
pagine: D332 - D354
SICI:
1093-9946(200103)6:<D332:PLAA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; TRIGLYCERIDE-RICH LIPOPROTEINS; RECEPTOR-RELATED PROTEIN; HEPARAN-SULFATE PROTEOGLYCANS; SMOOTH-MUSCLE CELLS; CORONARY-ARTERY DISEASE; APOE-DEFICIENT MICE; CHYLOMICRON-REMNANT CLEARANCE; MOUSE PERITONEAL-MACROPHAGES; INTERCELLULAR-ADHESION MOLECULE-1;
Keywords:
liver; cells; chylomicrons; chylomicron remnants; triglyceride-rich lipoproteins; apolipoprotein E; coronary heart disease; LDL receptor; LDL receptor-related-protein; heparan sulfate proteoglycans; hepatic lipase; endothelial smooth muscle cells; macrophages; review;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
287
Recensione:
Indirizzi per estratti:
Indirizzo: Cooper, AD Palo Alto Med Fdn, Res Inst, Ames Bldg,795 El Camino Real, PaloAlto, CA 94301 USA Palo Alto Med Fdn Ames Bldg,795 El Camino Real Palo Alto CA USA 94301
Citazione:
K.C.W. Yu e A.D. Cooper, "Postprandial lipoproteins and atherosclerosis", FRONT BIOSC, 6, 2001, pp. D332-D354

Abstract

During the postprandial state, dietary lipid is transported from the intestine to peripheral tissues by plasma lipoproteins called chylomicrons. In the capillary beds of peripheral tissues, chylomicron triglycerides are lipolyzed by the enzyme, lipoprotein lipase, allowing the delivery of free fatty acids to the cells. As a result, this produces a new particle of smaller size and enriched with cholesteryl ester referred to as chylomicron remnants. These particles are rapidly removed from the blood primarily by the liver. The liver has a complex chylomicron remnant removal system which is comprised of a combination of different mechanisms that include the low-density-lipoprotein receptor (LDLR) and the LDLR-related-protein (LRP). Furthermore, it has been suggested that there is a sequestration component whereby chylomicron remnants bind to heparan sulfate proteoglycans (HSPG) and/or hepatic lipase; this is then followed by transport to one or both of the above receptors for hepatic uptake. Over the years, a major concern has arisen about the association of chylomicron remnants and coronary heart disease (CHD) in man. Slow removal of chylomicron remnants, as reflected by a prolongedpostprandial state, is now commonly observed in patients with CHD and those that have abnormal lipid disorders such as hypertriglyceridemia, familialhypercholesterolemia, familial combined hyperlipidemia and non-insulin-dependent-diabetes-mellitus. The present review will focus on (a) the details of the metabolic pathway (exogenous pathway) that describes the two-step processing of postprandial lipoproteins, (b) the role of the liver, the receptors, and the importance of efficient removal of chylomicron remnants from the blood circulation, and (c) the potential atherogenic effects of chylomicron remnants on the arterial wall.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 15:25:46