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Titolo:
New agents for the medical treatment of interstitial cystitis
Autore:
Theoharides, TC; Sant, GR;
Indirizzi:
Tufts Univ, Sch Med, Dept Pharmacol & Expt Therapeut, Boston, MA 02111 USATufts Univ Boston MA USA 02111 col & Expt Therapeut, Boston, MA 02111 USA Tufts Univ, Sch Med, Dept Internal Med, Boston, MA 02111 USA Tufts Univ Boston MA USA 02111 d, Dept Internal Med, Boston, MA 02111 USA Tufts Univ, Sch Med, Dept Urol, Boston, MA 02111 USA Tufts Univ Boston MAUSA 02111 , Sch Med, Dept Urol, Boston, MA 02111 USA New England Med Ctr, Boston, MA 02111 USA New England Med Ctr Boston MA USA 02111 and Med Ctr, Boston, MA 02111 USA
Titolo Testata:
EXPERT OPINION ON INVESTIGATIONAL DRUGS
fascicolo: 3, volume: 10, anno: 2001,
pagine: 521 - 546
SICI:
1354-3784(200103)10:3<521:NAFTMT>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING HORMONE; MAST-CELL DEGRANULATION; RANDOMIZED CONTROLLED TRIAL; RAT URINARY-BLADDER; DOUBLE-BLIND TRIAL; INTRAVESICAL HYALURONIC-ACID; INDUCED HISTAMINE-SECRETION; NERVE-FIBER PROLIFERATION; BACILLUS-CALMETTE-GUERIN; PLACEBO-CONTROLLED TRIAL;
Keywords:
chondroitin sulphate; histamine-3 receptors; hyaluronic acid; inflammation; interstitial cystitis; mast cells; pain; quercetin;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
237
Recensione:
Indirizzi per estratti:
Indirizzo: Theoharides, TC Tufts Univ, Sch Med, Dept Pharmacol & Expt Therapeut, 136 Harrison Ave, Boston, MA 02111 USA Tufts Univ 136 Harrison Ave Boston MA USA 02111 02111 USA
Citazione:
T.C. Theoharides e G.R. Sant, "New agents for the medical treatment of interstitial cystitis", EXPERT OP I, 10(3), 2001, pp. 521-546

Abstract

Interstitial cystitis (IC) is a painful, sterile, disorder of the urinary bladder characterised by urgency. frequency?, nocturia and pain. IC occurs primarily in women but also in men with recent findings indicating that chronic, abacterial prostatitis may be a variant uf this condition. The prevalence of IC has ranged from about 8 - 60 cases/100,000 female patients depending on the population evaluated. About 10% of patients have severe symptoms that are associated with Hunner's ulcers on bladder biopsy; the rest could be grouped in those with or without bladder inflammation. Symptoms of IC Lire exacerbated by stress, certain foods and ovulatory hormones. Man). patients also experience allergies, irritable bowel syndrome (IUS) and migraines. There have been various reports indicating dysfunction of the bladder glycosaminoglycan (GAG) protective layer and man!: publications showing a high number of activated bladder mast cells. Increasing evidence suggests that neurogenic inflammation and/or neuropathic pain is a major component of IC pathophysiology. Approved treatments so far include intravesical administration of dimethylsulphoxide (DMSO) or oral pentosanpolysulphate (PPS). Newtreatments focus on the combined use of drugs tl-lat modulate bladder sensory nerve stimulation (neurolytic agents). inhibit neurogenic activation ofmast cells, or provide urothelial cytoprotection together R with new drugswith anti-inflammatory activity

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 03:27:44