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Titolo:
Evidence for involvement of dysfunctional teeth in the senile process in the hippocampus of SAMP8 mice
Autore:
Watanabe, K; Tonosaki, K; Kawase, T; Karasawa, N; Nagatsu, I; Fujita, M; Onozuka, M;
Indirizzi:
Kanagawa Dent Coll, Dept Dent Bioengn, Yokosuka, Kanagawa 2388580, Japan Kanagawa Dent Coll Yokosuka Kanagawa Japan 2388580 anagawa 2388580, Japan Gifu Univ, Sch Med, Dept Physiol, Gifu 5008705, Japan Gifu Univ Gifu Japan 5008705 Sch Med, Dept Physiol, Gifu 5008705, Japan Gifu Univ, Fac Agr, Dept Vet Physiol, Gifu 5011193, Japan Gifu Univ GifuJapan 5011193 Agr, Dept Vet Physiol, Gifu 5011193, Japan Fujita Hlth Univ, Sch Med, Dept Anat, Toyoake, Aichi 4701192, Japan FujitaHlth Univ Toyoake Aichi Japan 4701192 oyoake, Aichi 4701192, Japan Gifu Univ, Sch Med, Dept Anat, Div 2, Gifu 5008705, Japan Gifu Univ GifuJapan 5008705 Med, Dept Anat, Div 2, Gifu 5008705, Japan
Titolo Testata:
EXPERIMENTAL GERONTOLOGY
fascicolo: 2, volume: 36, anno: 2001,
pagine: 283 - 295
SICI:
0531-5565(200102)36:2<283:EFIODT>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
SENESCENCE-ACCELERATED MOUSE; AFFERENT ACTIVITY BLOCKADE; AGE-RELATED-CHANGES; SPATIAL MEMORY; STEREOLOGICAL ESTIMATION; ANIMAL-MODEL; AGING BRAIN; MOLAR TEETH; NEURONS; RATS;
Keywords:
mastication; senile dementia; spatial memory; hippocampal neuronal degeneration; SAMP8 mice;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Onozuka, M Gifu Univ, Sch Med, Dept Anat, Div 2, Gifu 5008705, Japan Gifu Univ Gifu Japan 5008705 Anat, Div 2, Gifu 5008705, Japan
Citazione:
K. Watanabe et al., "Evidence for involvement of dysfunctional teeth in the senile process in the hippocampus of SAMP8 mice", EXP GERONT, 36(2), 2001, pp. 283-295

Abstract

In order to evaluate the involvement of dysfunctional teeth in age-relateddeficits in hippocampal function, we examined the effect of removal of molar teeth (molarless condition) on neuronal degeneration and glial fibrous acidic protein (GFAP) expression in the hippocampus and on learning ability in a water maze test in young, middle-aged, and aged accelerated senescence-prone mice (SAMP8). The molarless condition enhanced an age-dependent decrease in both learning ability and the number of neurons in the hippocampal CA1 subfield and the age-dependent increase in the number and hypertrophy of GFAP-labeled astrocytes in the same subfield. These observations suggest that the molarless condition may be involved in the senile process in the hippocampus in SAMP8 mice. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 17:52:33