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Titolo:
Aging-induced changes in 24-h rhythms of mitogenic responses, lymphocyte subset populations and neurotransmitter and amino acid content in rat submaxillary lymph nodes during Freund's adjuvant arthritis
Autore:
Bonacho, MG; Cardinali, DP; Castrillon, P; Cutrera, RA; Esquifino, AI;
Indirizzi:
Univ Buenos Aires, Fac Med, Dept Fisiol, RA-1053 Buenos Aires, DF, Argentina Univ Buenos Aires Buenos Aires DF Argentina RA-1053 Aires, DF, Argentina Univ Complutense Madrid, Fac Med, Dept Bioquim & Biol Mol 3, Madrid, SpainUniv Complutense Madrid Madrid Spain ioquim & Biol Mol 3, Madrid, Spain
Titolo Testata:
EXPERIMENTAL GERONTOLOGY
fascicolo: 2, volume: 36, anno: 2001,
pagine: 267 - 282
SICI:
0531-5565(200102)36:2<267:ACI2RO>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
ORNITHINE DECARBOXYLASE ACTIVITY; PITUITARY-ADRENAL AXIS; ACETYLCHOLINE SYNTHESIS; AGED RATS; CIRCADIAN-RHYTHM; GENE-EXPRESSION; DIURNAL RHYTHMS; SPLEEN; NOREPINEPHRINE; CYCLOSPORINE;
Keywords:
submaxillary lymph nodes; aging; Freund's adjuvant; circadian rhythms; concanavalin A; lipopolysaccharide; lymphocyte subsets; norepinephrine; serotonin; aspartate; glutamate; taurine; GABA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Cardinali, DP Univ Buenos Aires, Fac Med, Dept Fisiol, RA-1053 Buenos Aires, DF, Argentina Univ Buenos Aires Buenos Aires DF Argentina RA-1053 gentina
Citazione:
M.G. Bonacho et al., "Aging-induced changes in 24-h rhythms of mitogenic responses, lymphocyte subset populations and neurotransmitter and amino acid content in rat submaxillary lymph nodes during Freund's adjuvant arthritis", EXP GERONT, 36(2), 2001, pp. 267-282

Abstract

In young (two months) and aged (18 months) male rats injected s.c. with Freund's adjuvant or adjuvant's vehicle 18 days earlier, 24-h variations in mitogenic responses, lymphocyte subsets and monoamine and amino acid contentwere examined in submaxillary lymph nodes. Mitogenic responses to concanavalin A (Con A) and lipopolysaccharide (LPS) were higher during the light phase of daily photoperiod. Old rats exhibited a suppressed or impaired mitogenic response to Con A but not to LPS. Acrophases of 24-h rhythm in lymphocyte subset populations in submaxillary lymph nodes were: 18:37-19:44 h (B cells), 09:00-10:08 h (T and CD4(+) cells) and 12:19-15:58 h (CD8(+) cells). Aging augmented B cells and decreased T, CD4(+) and CD8(+) cells. Significant correlations were found between Con A activity and T cells, between lymph node 5HT content and B, T and CD8(+) lymphocytes, and between lymph node5HT and taurine and GABA content. Aging increased lymph node 5HT content but did not modify NE content. Lymph node concentration of aspartate, glutamate and taurine was higher at night while that of GABA attained peak valuesat late afternoon. Old rats injected with Freund's adjuvant showed a higher mean value (glutamate) and smaller amplitude (glutamate, taurine) than their respective young controls. The results further document the effects of aging on the chronobiology of the immune system. (C) 2001 Elsevier Science Inc. All rights reserved.

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Documento generato il 10/04/20 alle ore 02:15:10