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Titolo:
Long-term treatment of chronic schizophrenia with risperidone: a study with plasma levels
Autore:
Mauri, MC; Laini, V; Boscati, L; Rudelli, R; Salvi, V; Orlandi, R; Papa, P;
Indirizzi:
Univ Milan, Dept Clin Psychiat, Clin Neuropharmacol Unit, IRCCS,Osped Maggiore, I-20122 Milan, Italy Univ Milan Milan Italy I-20122 RCCS,Osped Maggiore, I-20122 Milan, Italy Policlin San Matteo, IRCCS, Dept Toxicol, I-27100 Pavia, Italy Policlin San Matteo Pavia Italy I-27100 pt Toxicol, I-27100 Pavia, Italy
Titolo Testata:
EUROPEAN PSYCHIATRY
fascicolo: 1, volume: 16, anno: 2001,
pagine: 57 - 63
SICI:
0924-9338(200102)16:1<57:LTOCSW>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; 9-HYDROXYRISPERIDONE; PHARMACOKINETICS; MULTICENTER; CLOZAPINE; HUMANS;
Keywords:
9-hydroxy-risperidone; pharmacokinetics; plasma levels; risperidone; schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Mauri, MC Univ Milan, Dept Clin Psychiat, Clin Neuropharmacol Unit, IRCCS,Osped Maggiore, Via F Storza 35, I-20122 Milan, Italy Univ Milan Via F Storza 35 Milan Italy I-20122 122 Milan, Italy
Citazione:
M.C. Mauri et al., "Long-term treatment of chronic schizophrenia with risperidone: a study with plasma levels", EUR PSYCHIA, 16(1), 2001, pp. 57-63

Abstract

Twenty-four chronic schizophrenic outpatients with a mean age of 37.21 years +/- 9.96 SD were treated with risperidone (RSP) at the dosage of 2-9 mg/die (mean 4.46 mg/die +/- 1.30 SD, mean 0.06 mg/kg +/- 0.01 SD) for a year. Clinical evaluation was assessed with the Brief Psychiatric Rating Scale (BPRS), Positive and Negative Symptoms Scale (PANSS), Extrapyramidal Side Effects Rating Scale (EPSE) and a checklist for Anticholinergic Side Effects (ACS) at TD, then after 1 (T1), 2 (T2), 3 (T3), 6 (T6), 9 (T9) and 12 (T12)months. RSP and 9-hydroxy-risperidone (SOH-RSP) plasma levels were determined at T12 by the HPLC method. BPRS and PANSS mean values showed a significant improvement during the study. No correlation between RSP dosage (mg/kg)and RSP, SOH-RSP plasma levels or active moiety resulted. A positive correlation between age and active moiety was observed. A positive correlation between RSP and SOH-RSP plasma levels was observed. A curvilinear relationship between active moiety and PANSS improvement (%) was observed. Patients with the higher PANSS amelioration showed RSP + 9OH-RSP plasma levels ranging from 15 to 30 ng/mL. RSP seems to be quite an effective drug. It seems, however, difficult to devise appropriate dose schedules and plasma level determination seems to be necessary in some cases. (C) 2001 iditions scientifiques et medicales Elsevier SAS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 16:44:37