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Titolo:
Comparative effects of pharmacotherapy on the maintenance of cognitive function
Autore:
Allain, H; Schuck, S; Mauduit, N; Djemai, M;
Indirizzi:
Univ Rennes 1, Fac Med, Dept Pharmacol, F-35043 Rennes, France Univ Rennes1 Rennes France F-35043 pt Pharmacol, F-35043 Rennes, France
Titolo Testata:
EUROPEAN PSYCHIATRY
, volume: 16, anno: 2001, supplemento:, 1
pagine: 35S - 41S
SICI:
0924-9338(200101)16:<35S:CEOPOT>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; ALZHEIMERS-DISEASE; VASCULAR DEMENTIA; DOUBLE-BLIND; DIAGNOSTIC-CRITERIA; ELDERLY PATIENTS; GINKGO-BILOBA; PLACEBO; SCHIZOPHRENIA; AGITATION;
Keywords:
antipsychotics; clinical trials; cognition; dementia; memory; pharmacovigilance;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
76
Recensione:
Indirizzi per estratti:
Indirizzo: Allain, H Univ Rennes 1, Fac Med, Dept Pharmacol, 2 Ave Prof Leon Bernard,F-35043 Rennes, France Univ Rennes 1 2 Ave Prof Leon Bernard Rennes France F-35043 nce
Citazione:
H. Allain et al., "Comparative effects of pharmacotherapy on the maintenance of cognitive function", EUR PSYCHIA, 16, 2001, pp. 35S-41S

Abstract

The quality of human cognitive performance appears today as one of the main components of quality of life, whatever the age. Ageing by itself and most of the diseases affecting the central nervous system alter higher brain functions such as memory, vigilance and attention. Dementia is the most acute example, with a cascade of behavioral and psychological consequences (BPSD), which are the main cause of the caregiver's burden and need specific pharmacotherapy. In this respect, the problem will be the choice of the best drug in situations such as wandering, agitation, violence, and screaming. The psychotropics, however, should not deteriorate the already disturbed cognition of the patients. This is the reason why we propose to establish for each drug, and notably for the antipsychotics, a precise and exact 'cognitive mapping'; in other words, to measure the effects of drugs on the different components of cognition. The results of such studies will be predictive of the future phase III clinical trials and therapeutic responses. As an illustration of this approach we shall relate two studies, TIATEM (phase I) and TIAGE (phase III/IV), leading to the determination of a good cognitive safety profile of an atypical neuroleptic drug, tiapride. (C) 2001 Editions scientifiques et medicales Elsevier SAS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/06/20 alle ore 01:47:43