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Titolo:
The effects of grapefruit juice on the pharmacokinetics of erythromycin
Autore:
Kanazawa, S; Ohkubo, T; Sugawara, K;
Indirizzi:
Hirosaki Univ Hosp, Dept Pharm, Hirosaki, Aomori 0368563, Japan Hirosaki Univ Hosp Hirosaki Aomori Japan 0368563 i, Aomori 0368563, Japan
Titolo Testata:
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
fascicolo: 11, volume: 56, anno: 2001,
pagine: 799 - 803
SICI:
0031-6970(200101/02)56:11<799:TEOGJO>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; DRUG-INTERACTIONS; MACROLIDE ANTIBIOTICS; ELECTROCHEMICAL DETECTION; P-GLYCOPROTEIN; FELODIPINE; LIVER; DISPOSITION; MECHANISM; MIDAZOLAM;
Keywords:
erythromycin; grapefruit juice; cytochrome P450 3A4;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Ohkubo, T Hirosaki Univ Hosp, Dept Pharm, Hirosaki, Aomori 0368563, Japan Hirosaki Univ Hosp Hirosaki Aomori Japan 0368563 0368563, Japan
Citazione:
S. Kanazawa et al., "The effects of grapefruit juice on the pharmacokinetics of erythromycin", EUR J CL PH, 56(11), 2001, pp. 799-803

Abstract

Objective: To study the effects of grapefruit juice on the pharmacokinetics of erythromycin. Methods : The effects of grapefruit juice intake on the pharmacokinetics of erythromycin were investigated in six healthy male volunteers, who received 400 mg erythromycin with either water or grapefruit juice. The measurement of erythromycin in plasma samples were achieved by simple Sep-Pak CN cartridge extraction coupled with the electrochemical determination HPLC method, which was developed for the determination of erythromycin in human plasma in the present study. Results: Grapefruit juice, compared with water intake, significantly (P<0.05) increased the mean C-max value (1.65+/-0.94 versus 2.51+/-0.68 <mu>g/ml) and the mean AUC(0-12) value of erythromycin (5.92+/-3.25 versus 8.80+/-1.32 mug. h/ml). However, the T-max and t(1/2) Values of erythromycin were not affected by grapefruit juice intake. Conclusion: These results indicate that the bioavailability of erythromycin was increased by the inhibitory effect of grapefruit juice on cytochrome P450 (CYP) 3A4-mediated metabolism in the small intestine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 09:29:24