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Titolo:
Review of anthropometric factors and breast cancer risk
Autore:
Friedenreich, CM;
Indirizzi:
Alberta Canc Board, Div Epidemiol Prevent & Screening, Calgary, AB T2N 4N2, Canada Alberta Canc Board Calgary AB Canada T2N 4N2 Calgary, AB T2N 4N2, Canada
Titolo Testata:
EUROPEAN JOURNAL OF CANCER PREVENTION
fascicolo: 1, volume: 10, anno: 2001,
pagine: 15 - 32
SICI:
0959-8278(200102)10:1<15:ROAFAB>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
BODY-FAT DISTRIBUTION; POST-MENOPAUSAL WOMEN; GROWTH-FACTOR-I; DETECTION DEMONSTRATION PROJECT; HORMONE-BINDING GLOBULIN; BONE-MINERAL DENSITY; MIDDLE-AGED WOMEN; POSTMENOPAUSAL WOMEN; WEIGHT-GAIN; UNITED-STATES;
Keywords:
aetiology; anthropometric factors; body mass index; breast cancer; cancer prevention; height; review; weight; waist-hip ratio;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
171
Recensione:
Indirizzi per estratti:
Indirizzo: Friedenreich, CM Alberta Canc Board, Div Epidemiol Prevent & Screening, 1331-29 St NW, Calgary, AB T2N 4N2, Canada Alberta Canc Board 1331-29 St NW Calgary AB Canada T2N 4N2
Citazione:
C.M. Friedenreich, "Review of anthropometric factors and breast cancer risk", EUR J CAN P, 10(1), 2001, pp. 15-32

Abstract

Epidemiological evidence implicating anthropometric risk factors in breastcancer aetiology is accumulating. For premenopausal women, breast cancer risk increases with increasing height, but decreases with higher weight or body mass index, and no association with increased central adiposity exists. For postmenopausal women, an increased risk of breast cancer is found withincreasing levels of all the anthropometric variables including height, weight, body mass index, waist-hip ratio, waist circumference and weight gain. Weight loss appears to decrease risk, particularly if it occurs later in life. Breast size may be a risk factor for breast cancer, however, the current evidence is inconclusive. Several hypothesized biologic mechanisms exist to explain how anthropometric factors influence breast cancer risk. Obesity may increase levels of circulating endogenous sex hormones, insulin and insulin-like growth factors that all, in turn, increase breast cancer risk. Genetic predisposition to obesity and to specific body fat distributions are also implicated. With obesity, there are increased levels of fat tissue that can store toxins and can serve as a continuous source of carcinogens, Recommendations for future research on anthropometric factors and breast cancer are provided, Sufficient evidence exists to support strategies to avoid weight gain throughout life as a means of reducing postmenopausal breast cancer risk. (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 16:32:04