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Titolo:
Omega-3 fatty acids improve blood pressure control and preserve renal function in hypertensive heart transplant recipients
Autore:
Holm, T; Andreassen, AK; Aukrust, P; Andersen, K; Geiran, OR; Simonsen, S; Gullestad, L;
Indirizzi:
Univ Oslo, Rikshosp, Internal Med Res Inst, N-0027 Oslo, Norway Univ OsloOslo Norway N-0027 Internal Med Res Inst, N-0027 Oslo, Norway Univ Oslo, Rikshosp, Dept Cardiol, N-0027 Oslo, Norway Univ Oslo Oslo Norway N-0027 Rikshosp, Dept Cardiol, N-0027 Oslo, Norway Univ Oslo, Rikshosp, Dept Thorac Surg, N-0027 Oslo, Norway Univ Oslo Oslo Norway N-0027 hosp, Dept Thorac Surg, N-0027 Oslo, Norway Univ Oslo, Rikshosp, Dept Med, Sect Clin Immunol & Infect Dis, N-0027 Oslo, Norway Univ Oslo Oslo Norway N-0027 n Immunol & Infect Dis, N-0027 Oslo, Norway
Titolo Testata:
EUROPEAN HEART JOURNAL
fascicolo: 5, volume: 22, anno: 2001,
pagine: 428 - 436
SICI:
0195-668X(200103)22:5<428:OFAIBP>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIETARY FISH-OIL; CARDIAC TRANSPLANTATION; CYCLOSPORINE; OMEGA-3-FATTY-ACIDS; METAANALYSIS; MECHANISMS; RESPONSES; HUMANS;
Keywords:
heart transplantation; hypertension; omega-3; fatty acids; kidney; endothelium;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Holm, T Univ Oslo, Rikshosp, Internal Med Res Inst, Sognsvannsvn 20, N-0027 Oslo, Norway Univ Oslo Sognsvannsvn 20 Oslo Norway N-0027 N-0027 Oslo, Norway
Citazione:
T. Holm et al., "Omega-3 fatty acids improve blood pressure control and preserve renal function in hypertensive heart transplant recipients", EUR HEART J, 22(5), 2001, pp. 428-436

Abstract

Background Hypertension and cyclosporine-induced nephrotoxicity are commoncomplications in heart transplant recipients. Omega-3 fatty acids may prevent blood pressure rise early, but have not been studied long-term after heart transplantation. Methods and Results Forty-five clinically stable hypertensive heart transplant recipients were studied 1-12 years after transplantation and randomized in a double-blind fashion to receive either 3.4 g of omega-3 fatty acids daily or placebo for 1 year. Ambulatory 24 h blood pressure monitoring and haemodynamic studies were performed before randomization and at the end of the study. Systolic blood pressure increased by 8 +/- 3 mmHg (P<0.01) in the placebo group, with a non-significant increase in diastolic blood pressure of 3 +/- 2 mmHg (P=0.10), accompanied by a 14% increase in systemic vascular resistance (P<0.05). In contrast, no change in blood pressure or systemic vascular resistance was recorded in the omega-3 group. Plasma creatinineincreased (P<0.01) and glomerular filtration rate decreased (P<0.05) in the placebo group, while no changes were observed in the omega-3 group. The antihypertensive effect was related to an increase in serum eicosapentaenoicand docosahexaenoic acid. Conclusion Treatment with omega-3 fatty acids may reduce the long-term continuous rise in blood pressure after heart transplantation and may offer a direct or indirect renoprotective effect, making these fatty acids a potentially attractive treatment for post-transplant hypertension. (Eur Heart J 2001; 22: 428-136, doi:10, 1053/euhj.2000.2369) (C) 2001 The European Society of Cardiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 16:46:49