Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Oral sustained-release bioadhesive tablet formulation of didanosine
Autore:
Betageri, GV; Deshmukh, DV; Gupta, RB;
Indirizzi:
Western Univ Hlth Sci, Pomona, CA 91766 USA Western Univ Hlth Sci Pomona CA USA 91766 Hlth Sci, Pomona, CA 91766 USA Auburn Univ, Sch Pharm, Dept Pharmacal Sci, Auburn, AL 36849 USA Auburn Univ Auburn AL USA 36849 Dept Pharmacal Sci, Auburn, AL 36849 USA Auburn Univ, Coll Engn, Dept Chem Engn, Auburn, AL 36849 USA Auburn Univ Auburn AL USA 36849 ngn, Dept Chem Engn, Auburn, AL 36849 USA
Titolo Testata:
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
fascicolo: 2, volume: 27, anno: 2001,
pagine: 129 - 136
SICI:
0363-9045(2001)27:2<129:OSBTFO>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONTROLLED DRUG DELIVERY; HYDROGEL MATRICES; 2',3'-DIDEOXYINOSINE; POLYMER; SYSTEMS;
Keywords:
bioadhesion; didanosine (ddI); hydrogel; polymer; sustained-release; tablets;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Betageri, GV Western Univ Hlth Sci, 309 E 2nd St, Pomona, CA 91766 USA Western Univ Hlth Sci 309 E 2nd St Pomona CA USA 91766 66 USA
Citazione:
G.V. Betageri et al., "Oral sustained-release bioadhesive tablet formulation of didanosine", DRUG DEV IN, 27(2), 2001, pp. 129-136

Abstract

The objective of this study was to formulate a hydrogel-forming bioadhesive drug delivery system for oral administration of didanosine (ddI). The aimof this tablet dosage form is to improve the oral absorption of ddI by delivering it in small doses over an extended period and localizing it in the intestine by bioadhesion. Compressed tablets of ddI using Polyox(R) WSRN-303, Carbopol(R) 974-NF, and Methocel(R) K4M as the bioadhesive release rate-controlling polymers were prepared. The effect of polymer concentration on the release profile and in vitro bioadhesion of the matrix tablets was studied. Tablet formulations with Polyox WSRN-303 (10%) and Methocel K4M (30%) showed 93 and 90% drug release, respectively, after 12 h. The drug release was found to be linear when fitted in the Higuchi equation (square-root time equation), suggesting zero-order release. Carbopol 974-P-NF was found to inhibit the complete release of ddI because of drug-polymer interaction; hence, is not suitable for formulation of ddI. Drug diffusion and swelling ofthe polymer (anomalous Fickian release) was found dominant in ddI release. In general, in vitro bioadhesion increased with an increase in polymer concentration. Tablets containing a single polymer can be designed to form hydrogels serving the dual purpose of bioadhesion and sustained release.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 23:13:55