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Titolo:
Antioxidant treatment in hereditary pancreatitis. A pilot study on three young patients
Autore:
Uomo, G; Talamini, G; Rabitti, PG;
Indirizzi:
Cardarelli Hosp, Dept Internal Med, Div 3, I-80131 Naples, Italy Cardarelli Hosp Naples Italy I-80131 l Med, Div 3, I-80131 Naples, Italy Univ Verona, Dept Med & Surg, I-37100 Verona, Italy Univ Verona Verona Italy I-37100 Dept Med & Surg, I-37100 Verona, Italy
Titolo Testata:
DIGESTIVE AND LIVER DISEASE
fascicolo: 1, volume: 33, anno: 2001,
pagine: 58 - 62
SICI:
1590-8658(200101/02)33:1<58:ATIHPA>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLACEBO-CONTROLLED TRIAL; RECURRENT PANCREATITIS; SURGICAL THERAPY; OXIDATIVE STRESS; FOLLOW-UP;
Keywords:
acute pancreatitis; antioxidant vitamins; chronic pancreatitis; hereditary pancreatitis; selenium supplementation; sulphadenosyl-methionine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Uomo, G Cardarelli Hosp, Dept Internal Med, Div 3, Via Cardarelli 9, I-80131 Naples, Italy Cardarelli Hosp Via Cardarelli 9 Naples Italy I-80131 ples, Italy
Citazione:
G. Uomo et al., "Antioxidant treatment in hereditary pancreatitis. A pilot study on three young patients", DIG LIVER D, 33(1), 2001, pp. 58-62

Abstract

Background. Abdominal pain is the most challenging symptom of hereditary pancreatitis. No specific and proven therapy is yet available; analgesics, often in large doses, are required also in children and young patients. Patients and Methods. We performed an open-label, pilot study on three young patients, coming from the same kindred, with hereditary pancreatitis. The study period lasted two years (July 1997-July 1999) and was divided into four sub-periods of six months each. In the first and third period the patients took only oral analgesics, if necessary; in the second and fourth period, an antioxidant regimen per os was added. This treatment consisted of sulphadenosyl-methionine (800 mg per day), Vitamin C (180 mg per day), Vitamin E (30 mg per day), Vitamin A (2400 mug per day), and selenium (75 mug perday). Results. Compliance of patients to the treatment schedule was satisfactoryand no important side-effects were observed. Antioxidant treatment led to a significant reduction (p<0.05) in the number of days with abdominal pain experienced by the three patients and this was verified for both periods oftreatment. Albeit, consumption of analgesics was lower in the antioxidant treatment periods. Conclusions. Oxidative stress may be one of the principle contributors to pain in hereditary pancreatitis and orally administered antioxidant treatment appears to be effective for control of the condition, in young patients,suffering from this rare disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 01:33:02