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Titolo:
Bacterial infection in patients with advanced cirrhosis: a multicentre prospective study
Autore:
Borzio, M; Salerno, F; Piantoni, L; Cazzaniga, M; Angeli, P; Bissoli, F; Boccia, S; Colloredo-Mels, G; Corigliano, P; Fornaciari, G; Marenco, G; Pistara, R; Salvagnini, M; Sangiovanni, A;
Indirizzi:
Fatebenefratelli Hosp, Dept Med, I-20121 Milan, Italy Fatebenefratelli Hosp Milan Italy I-20121 Dept Med, I-20121 Milan, Italy IRCCS Polyclin, Dept Internal Med, Milan, Italy IRCCS Polyclin Milan Italy CS Polyclin, Dept Internal Med, Milan, Italy Polyclin Padua, Dept Med, Padua, Italy Polyclin Padua Padua ItalyPolyclin Padua, Dept Med, Padua, Italy Fornaroli Hosp, Div Med, Magenta, MI, Italy Fornaroli Hosp Magenta MI Italy naroli Hosp, Div Med, Magenta, MI, Italy S Anna Hosp, Gastroenterol Unit, Ferrara, Italy S Anna Hosp Ferrara Italy Anna Hosp, Gastroenterol Unit, Ferrara, Italy Bolognini Hosp, Div Med, Seriate, Italy Bolognini Hosp Seriate ItalyBolognini Hosp, Div Med, Seriate, Italy Cantu Hosp, Div Med, Abbiategrasso, Italy Cantu Hosp Abbiategrasso Italy antu Hosp, Div Med, Abbiategrasso, Italy Reggio Emilia Hosp, Div Med, Reggio Emilia, Italy Reggio Emilia Hosp Reggio Emilia Italy p, Div Med, Reggio Emilia, Italy Santa Corona Hosp, Div Med, Pietra Ligure, Italy Santa Corona Hosp PietraLigure Italy sp, Div Med, Pietra Ligure, Italy Busto Arsizio Hosp, Div Med, Busto Arsizio, Italy Busto Arsizio Hosp Busto Arsizio Italy p, Div Med, Busto Arsizio, Italy Vicenza Hosp, Div Med, Vicenza, Italy Vicenza Hosp Vicenza ItalyVicenza Hosp, Div Med, Vicenza, Italy Valduce Hosp, Div Med, Gastroenterol Unit, Como, Italy Valduce Hosp ComoItaly Hosp, Div Med, Gastroenterol Unit, Como, Italy
Titolo Testata:
DIGESTIVE AND LIVER DISEASE
fascicolo: 1, volume: 33, anno: 2001,
pagine: 41 - 48
SICI:
1590-8658(200101/02)33:1<41:BIIPWA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
GASTROINTESTINAL HEMORRHAGE; ANTIBIOTIC-PROPHYLAXIS; PREDICTIVE FACTORS; RISK-FACTORS; LIVER-DISEASE; PERITONITIS; RECURRENCE; CIRRHOTICS; PROGNOSIS; FREQUENCY;
Keywords:
bacterial infections; cirrhosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Borzio, M Fatebenefratelli Hosp, Dept Med, Cso Porta Nuova 23, I-20121 Milan, Italy Fatebenefratelli Hosp Cso Porta Nuova 23 Milan Italy I-20121 ly
Citazione:
M. Borzio et al., "Bacterial infection in patients with advanced cirrhosis: a multicentre prospective study", DIG LIVER D, 33(1), 2001, pp. 41-48

Abstract

Aims. To evaluate the prevalence, incidence and clinical relevance of bacterial infection in predominantly non-alcoholic cirrhotic patients hospitalised for decompensation. Patients/Methods. A total of 405 consecutive admissions in 361 patients (249 males and 112 females; 66 Child-Pugh class B and 295 class C) were analysed. Blood, urine, ascitic and pleural fluid cultures were performed withinthe first 24 hours, during hospitalisation whenever infection was suspected, and again before discharge. Results. Over a one year period, 150 (34%) bacterial infections (89 community- and 61 hospital-acquired) involving urinary tract (41%), ascites (23%), blood (21%) and respiratory tract (17%) were diagnosed. The prevalence ofbacterial peritonitis was 12%. infections were asymptomatic in 89 cases (46%) and 130(87%) involved a single site. Enteric flora accounted for 62% ofinfections, Escherichia Coli being the most frequent pathogen (25%). Community-acquired infections were associated with more advanced liver disease (Child-Pugh mean score 10.2 +/- 2.1 versus 9.5 +/- 1.9, p < 0.05), renal failure (p < 0.05), and high white blood cell count (p < 0.01). Hospital-acquired infections occurred more frequently in patients admitted for gastrointestinal bleeding (p < 0.05). The in-hospital mortality was significantly higher in infected than in non-infected patients (15% versus 7%, p < 0.05), and infection emerged as an independent variable affecting survival, Moreover, bacterial infection accounted for a significantly prolonged hospital stayConclusions. Bacterial infection, regardless of the aetiology, is a severecomplication of decompensated cirrhosis, and, although frequently asymptomatic, accounts for both longer hospital stay and increased mortality.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:25:26