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Titolo:
Increased prevalence of Helicobacter pylori in patients with diabetes mellitus
Autore:
Marrollo, M; Latella, G; Melideo, D; Storelli, E; Iannarelli, R; Stornelli, P; Valenti, M; Caprilli, R;
Indirizzi:
Univ Aquila, Cattedra Gastroenterol, Dipartimento Med Interna, Gastroenterol Unit, I-67100 Laquila, Italy Univ Aquila Laquila Italy I-67100 roenterol Unit, I-67100 Laquila, Italy San Salvatore Hosp, Diabetol Unit, Laquila, Italy San Salvatore Hosp Laquila Italy re Hosp, Diabetol Unit, Laquila, Italy Univ Aquila, Med Stat Unit, I-67100 Laquila, Italy Univ Aquila Laquila Italy I-67100 Med Stat Unit, I-67100 Laquila, Italy Univ Rome La Sapienza, Gastroenterol Unit 1, Rome, Italy Univ Rome La Sapienza Rome Italy nza, Gastroenterol Unit 1, Rome, Italy
Titolo Testata:
DIGESTIVE AND LIVER DISEASE
fascicolo: 1, volume: 33, anno: 2001,
pagine: 21 - 29
SICI:
1590-8658(200101/02)33:1<21:IPOHPI>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
MIGRATING MOTOR COMPLEX; NONULCER DYSPEPSIA; AUTONOMIC NEUROPATHY; PEPTIC-ULCER; INFECTION; GASTRITIS; GASTROPARESIS; DISORDERS; MOTILITY; METOCLOPRAMIDE;
Keywords:
chronic gastritis; diabetes mellitus; Helicobacter pylori; peptic disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
78
Recensione:
Indirizzi per estratti:
Indirizzo: Latella, G Univ Aquila, Cattedra Gastroenterol, Dipartimento Med Interna, Gastroenterol Unit, Via S Sisto 22E, I-67100 Laquila, Italy Univ Aquila ViaS Sisto 22E Laquila Italy I-67100 quila, Italy
Citazione:
M. Marrollo et al., "Increased prevalence of Helicobacter pylori in patients with diabetes mellitus", DIG LIVER D, 33(1), 2001, pp. 21-29

Abstract

Background. Whilst upper gastrointestinal disturbances are frequently observed in patients with diabetes mellitus, little is known about the prevalence of Helicobacter pylori infection and peptic disease in these patients. Aim. To evaluate prevalence of Helicobacter pylori infection and peptic disease lesions in diabetics with dyspeptic symptoms. Patients and methods. Study population comprises 74 consecutive diabetes mellitus patients with dyspepsia and 117 consecutive non diabetic dyspeptic patients. Upon enrolment, each patient completed an interview screening questionnaire to obtain information concerning presence and severity of dyspepsia. AII patients underwent upper gastrointestinal endoscopy with biopsy specimens being collected from gastric antrum and body. Helicobacter pylori was evaluated in each patient by rapid urease test and histology (Giemsa). Gastritis was classified according to the Sydney System. Statistical analysis was performed by chi-square, Fisher exact or t test and logistic regression analysis. A p value <0.05 was considered significant. Results. Prevalence of Helicobacter pylori infection was found to be significantly higher in diabetics than in controls. The prevalence rate of endoscopic lesions was comparable in the two groups, but the association betweenendoscopic lesions and Helicobacter pylori infection was significantly higher in diabetics. Overall, the presence of chronic gastritis, both non atrophic and atrophic, as well as intestinal metaplasia were comparable in the two groups of patients, whilst the association between chronic gastritis and Helicobacter pylori infection or gastritis activity were significantly higher in diabetics. In neither group, was any correlation found between severity of dyspepsia and presence of endoscopic lesions, chronic gastritis or Helicobacter pylori infection. Conclusions. These data show a higher prevalence of Helicobacter pylori infection in diabetes mellitus patients with dyspepsia. Helicobacter pylori infection was significantly associated both with the presence of endoscopic lesions and chronic gastritis in diabetic patients, but not in the controls.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 08:33:26