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Titolo:
Towards a novel treatment strategy for acute pancreatitis - 1. Reappraisalof the evidence on aetiogenesis
Autore:
Braganza, JM;
Indirizzi:
Manchester Royal Infirm, Manchester M13 9WL, Lancs, England Manchester Royal Infirm Manchester Lancs England M13 9WL , Lancs, England
Titolo Testata:
DIGESTION
fascicolo: 2, volume: 63, anno: 2001,
pagine: 69 - 91
SICI:
0012-2823(2001)63:2<69:TANTSF>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLATELET-ACTIVATING-FACTOR; INFLAMMATORY RESPONSE SYNDROME; RAT EXOCRINE PANCREAS; TUMOR-NECROSIS-FACTOR; ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY; ACUTE NECROTIZING PANCREATITIS; CYSTIC-FIBROSIS GENE; OXYGEN-FREE RADICALS; MAST-CELL TRYPTASE; OXIDATIVE STRESS;
Keywords:
acute pancreatitis aetiogenesis; autodigestion; colocalization; signal transduction; oxidative stress; xenobiotics; mast cell; anaphylactoid reaction; contact system; systemic inflammatory response syndrome multiple organ dysfunction syndrome;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
237
Recensione:
Indirizzi per estratti:
Indirizzo: Braganza, JM Manchester Royal Infirm, Pancreatobiliary Serv, Oxford Rd, Manchester M13 9WL, Lancs, England Manchester Royal Infirm Oxford Rd Manchester Lancs England M13 9WL
Citazione:
J.M. Braganza, "Towards a novel treatment strategy for acute pancreatitis - 1. Reappraisalof the evidence on aetiogenesis", DIGESTION, 63(2), 2001, pp. 69-91

Abstract

Despite more than a century of research endeavour, there is no specific medical treatment for acute pancreatitis and early mortality is high - 20% offatalities by the day after admission. I do not see any realistic prospectthat today's focus on immunomodulation will provide a breakthrough either. The signs are that the outcome of acute pancreatitis is determined almost at its inception, and that those unfortunate individuals in whom the seeds for a precipitous course are sewn do not declare themselves until it is toolate. This reappraisal of the evidence on disease aetiogenesis has been undertaken in an effort to fathom why this might be, Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 20:20:27