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Titolo:
Treatment of diabetes with vanadium salts: general overview and amelioration of nutritionally induced diabetes in the Psammomys obesus gerbil
Autore:
Shafrir, E; Spielman, S; Nachliel, I; Khamaisi, M; Bar-On, H; Ziv, E;
Indirizzi:
Hadassah Univ Hosp, Dept Biochem, IL-91120 Jerusalem, Israel Hadassah UnivHosp Jerusalem Israel IL-91120 IL-91120 Jerusalem, Israel Hadassah Univ Hosp, Diabet Res Unit, IL-91120 Jerusalem, Israel Hadassah Univ Hosp Jerusalem Israel IL-91120 IL-91120 Jerusalem, Israel Hebrew Univ Jerusalem, Hadassah Med Sch, IL-91120 Jerusalem, Israel HebrewUniv Jerusalem Jerusalem Israel IL-91120 -91120 Jerusalem, Israel
Titolo Testata:
DIABETES-METABOLISM RESEARCH AND REVIEWS
fascicolo: 1, volume: 17, anno: 2001,
pagine: 55 - 66
SICI:
1520-7552(200101/02)17:1<55:TODWVS>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH SUCROSE DIET; VANADATE NORMALIZES HYPERGLYCEMIA; PROTEIN-TYROSINE PHOSPHATASES; IMPROVES INSULIN SENSITIVITY; STIMULATE GLUCOSE-TRANSPORT; RAT ADIPOCYTES; ORAL VANADYL; IN-VIVO; ANIMAL-MODELS; MESSENGER-RNA;
Keywords:
nutritionally induced diabetes; insulin resistance; vanadyl sulfate; insulin receptor; tyrosine kinase; GLUT4; insulin potentiation;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
121
Recensione:
Indirizzi per estratti:
Indirizzo: Shafrir, E Hadassah Univ Hosp, Dept Biochem, IL-91120 Jerusalem, Israel Hadassah Univ Hosp Jerusalem Israel IL-91120 erusalem, Israel
Citazione:
E. Shafrir et al., "Treatment of diabetes with vanadium salts: general overview and amelioration of nutritionally induced diabetes in the Psammomys obesus gerbil", DIABET M R, 17(1), 2001, pp. 55-66

Abstract

Background Numerous investigations have demonstrated the beneficial effectof vanadium salts on diabetes in streptozotocin (STZ)-diabetic rats, in rodents with genetically determined diabetes and in human subjects. The amelioration of diabetes included the abolition of hyperglycemia, preservation of insulin secretion, reduction in hepatic glucose production, enhanced glycolysis and lipogenesis and improved muscle glucose uptake through GLUT4 elevation and translocation. The molecular basis of vanadium salt action is not yet Fully elucidated. Although evidence has been provided that the insulin receptor is activated, the possibility exists that cytosolic nonreceptor tyrosine kinase, direct phosphorylation of IRS-1 and activation of PI3-K, leading to GLUT4 translocation, are involved. The raised phosphorylation of proteins in the insulin signaling pathway appears to be related to the inhibition of protein tyrosine phosphatase (PTPase) activity by vanadium salts.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 12:14:07