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Titolo:
Abnormalities in apo B-containing lipoproteins in diabetes and atherosclerosis
Autore:
Tomkin, GH; Owens, D;
Indirizzi:
Univ Dublin Trinity Coll, Dept Endocrinol & Diabet, Dublin 2, Ireland UnivDublin Trinity Coll Dublin Ireland 2 ol & Diabet, Dublin 2, Ireland Adelaide & Meath Hosp, Dublin, Ireland Adelaide & Meath Hosp Dublin Ireland aide & Meath Hosp, Dublin, Ireland
Titolo Testata:
DIABETES-METABOLISM RESEARCH AND REVIEWS
fascicolo: 1, volume: 17, anno: 2001,
pagine: 27 - 43
SICI:
1520-7552(200101/02)17:1<27:AIABLI>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; TRIGLYCERIDE-RICH LIPOPROTEINS; CORONARY HEART-DISEASE; ACYL-COENZYME-A; MONOCYTE-DERIVED MACROPHAGES; FATTY-ACID COMPOSITION; ENDOTHELIUM-DEPENDENT VASORELAXATION; ISOLATED RABBIT ENTEROCYTES; CONTAINING IMMUNE-COMPLEXES; CELL-ADHESION MOLECULE-1;
Keywords:
diabetes; apo B lipoproteins; atherosclerosis; macrophages; endothelium;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
180
Recensione:
Indirizzi per estratti:
Indirizzo: Tomkin, GH 1 Fitzwilliam Sq, Dublin 2, Ireland 1 Fitzwilliam Sq Dublin Ireland 2 lliam Sq, Dublin 2, Ireland
Citazione:
G.H. Tomkin e D. Owens, "Abnormalities in apo B-containing lipoproteins in diabetes and atherosclerosis", DIABET M R, 17(1), 2001, pp. 27-43

Abstract

Atherosclerosis is the major cause of death in patients with diabetes. Low-density lipoprotein (LDL) being the most important cholesterol-carrying lipoprotein has been studied extensively in both diabetes and non-diabetes. This paper reviews the literature but also focuses on the precursors of LDL and in particular the postprandial apo B-containing lipoproteins. Abnormalities in the postprandial lipoproteins and alteration in chylomicron assembly and clearance are discussed and the evidence presented suggesting the importance of dysregulation of these lipoproteins in atherosclerotic progression. The relationship between chylomicron production in the intestine and hepatic release of very low-density lipoproteins (VLDL) is explored, as is the interrelationship between clearance rates of these lipoproteins. The sizeof LDL influences its atherogenicity. VLDL composition and size in relation to its influence on LDL is discussed. The effect of diet on the composition of lipoproteins and the relationship between fatty acid composition and clearance is reviewed. Evidence that diabetic control beneficially alters lipoprotein composition is presented suggesting how improved diabetic control may reduce atherosclerosis. The review concludes with a discussion on theeffect of the apo B-containing lipoproteins and their modification throughglycation and oxidation on macrophage and endothelial function. Copyright (C) 2001 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 11:10:54