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Titolo:
Effect of the treatment of Helicobacter pylori infection on gastric emptying and its influence on the glycaemic control in type 1 diabetes mellitus
Autore:
de Luis, DA; Cordero, JM; Caballero, C; Boixeda, D; Aller, R; Canton, R; de la Calle, H;
Indirizzi:
Hosp Rio Hortega, Inst Endocrinol & Nutr, Dept Endocrinol, Valladolid 47013, Spain Hosp Rio Hortega Valladolid Spain 47013 ocrinol, Valladolid 47013, Spain Univ Alcala de Henares, Hosp Ramon y Cajal, Dept Nucl Med, Madrid, Spain Univ Alcala de Henares Madrid Spain Cajal, Dept Nucl Med, Madrid, Spain Univ Alcala de Henares, Hosp Ramon y Cajal, Dept Gastroenterol, Madrid, Spain Univ Alcala de Henares Madrid Spain , Dept Gastroenterol, Madrid, Spain Univ Alcala de Henares, Hosp Ramon y Cajal, Dept Microbiol, Madrid, Spain Univ Alcala de Henares Madrid Spain ajal, Dept Microbiol, Madrid, Spain
Titolo Testata:
DIABETES RESEARCH AND CLINICAL PRACTICE
fascicolo: 1, volume: 52, anno: 2001,
pagine: 1 - 9
SICI:
0168-8227(200104)52:1<1:EOTTOH>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
CAMPYLOBACTER-PYLORIDIS; AUTONOMIC NEUROPATHY; BLOOD-GLUCOSE; HYPERGLYCEMIA; GASTROPARESIS; DIAGNOSIS; DYSPEPSIA; MOTILITY; LYMPHOMA; TRANSIT;
Keywords:
gastric emptying; Helicobacter pylori infection; type 1 diabetes mellitus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: de Luis, DA Hosp Rio Hortega, Inst Endocrinol & Nutr, Dept Endocrinol, C Camano 51 Bis,3oC, Valladolid 47013, Spain Hosp Rio Hortega C Camano 51 Bis,3oC Valladolid Spain 47013 n
Citazione:
D.A. de Luis et al., "Effect of the treatment of Helicobacter pylori infection on gastric emptying and its influence on the glycaemic control in type 1 diabetes mellitus", DIABET RE C, 52(1), 2001, pp. 1-9

Abstract

Helicobacter pylori (Hp) infection plays a role in gastric emptying (GE) in type 1 diabetic patients and may have implications for glycaemic control. The aim of our study was to investigate this relationship. Gastric emptying was studied in 13 patients with type 1 diabetes and Hp infection. The Hp infection status: was assessed by serology and urease breath test (UBT). Inaddition upper gastrointestinal endoscopy with gastric mucosal biopsy was performed to look for gastritis. A radionuclide-labeled solid meal was usedto study GE before and after eradication therapy (amoxicillin, clarithromycin and omeprazole) for tip infection. All patients were evaluated for autonomic and peripheral neuropathy and were asked for symptoms: of gastrointestinal motel dysfunction. Blood glucose levels were determined before the meal and at 30, 60, 90 and 120 min after the start of the meal. Home blood glucose self-monitoring and HbA(1c) were performed to document glycaemic control during the study. Three months after treatment, five patients were freeof Hp infection and were without gastritis (group I: no Hp infection, no gastritis): eight of the patients continued to have gastritis after treatment (group II) and of these eight patients, six had gastritis without Hp infection and two had gastritis plus persistent tip infection. These last two patients were re-treated with eradication therapy. Patients with gastritis were re-evaluated 6 months after initial treatment; at which time four were now free of gastritis and were added to group I (n = 9) while four continual to have gastritis although without Hp infection (group II, n = 4). In group I, GE half-time showed an increase (30.6 +/- 10.3 min vs. 60.2 +/- 15.4 min; P < 0.05) while no change (28.8 +/- 9.5 vs. 26.9 +/- 8.7 min; n.s.) was observed in group II. GE half-time was not altered by autonomic and peripheral neuropathy or blood glucose during solid meal test. HbA(1c) did not change significantly after treatment in either groups but the blood glucose levels were more stable in group I compared to group II. A delay in GE was observed with disappearance of gastritis associated to H. pylori infection after eradication treatment in patients with type 1 diabetes. This change in GE could help to stabilise the blood glucose levels in these patients treated with insulin before each meal. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

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Documento generato il 30/09/20 alle ore 09:38:51