Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Bullous pemphigoid in a patient treated with UVA-1 phototherapy for disseminated morphea
Autore:
Sacher, C; Konig, C; Scharffetter-Kochanek, K; Krieg, T; Hunzelmann, N;
Indirizzi:
Univ Cologne, Dept Dermatol, D-50924 Cologne, Germany Univ Cologne Cologne Germany D-50924 Dermatol, D-50924 Cologne, Germany
Titolo Testata:
DERMATOLOGY
fascicolo: 1, volume: 202, anno: 2001,
pagine: 54 - 57
SICI:
1018-8665(2001)202:1<54:BPIAPT>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
COEXISTENCE; THERAPY; AUTOANTIBODIES;
Keywords:
blistering disease; circumscribed scleroderma; light provocation; immunofluorescence;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Hunzelmann, N Univ Cologne, Klin & Poliklin Dermatol & Venerol, Joseph Stelzmann Str 9, D-50924 Cologne, Germany Univ Cologne Joseph Stelzmann Str 9 Cologne Germany D-50924
Citazione:
C. Sacher et al., "Bullous pemphigoid in a patient treated with UVA-1 phototherapy for disseminated morphea", DERMATOLOGY, 202(1), 2001, pp. 54-57

Abstract

Bullous pemphigoid is an autoimmune disease of the skin characterized by the production of antibodies directed at structures of the basement membranezone (BMZ) leading to subepidermal blisters. Several causative triggers have been described in the literature, among them UV light. Here, we report on a 73-year-old Caucasian female with disseminated morphea who developed blisters on her extremities after receiving whole-body UVA-1 phototherapy. The initial differential diagnosis of a phototoxic versus photoallergic reaction was ruled out as the lesions continued to spread after discontinuation of phototherapy. Histological and direct immunofluorescence examination showing a subepidermal blister and linear IgG deposits along the BMZ along with detection of circulating anti-BMZ antibodies led to the diagnosis of bullous pemphigoid. Immunosuppressive therapy resulted in regression of all blisters. After ruling out other possible causes, such as neoplasias or drugs,we conclude that UVA-1 has to be regarded as the most likely trigger of the disease. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/01/21 alle ore 23:21:27