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Titolo:
C-reactive protein and interleukin 6 receptor in post-traumatic stress disorder: A pilot study
Autore:
Miller, RJ; Sutherland, AG; Hutchison, JD; Alexander, DA;
Indirizzi:
Univ Aberdeen, Sch Med, Dept Orthopaed, Aberdeen AB9 2ZD, Scotland Univ Aberdeen Aberdeen Scotland AB9 2ZD paed, Aberdeen AB9 2ZD, Scotland Univ Aberdeen, Sch Med, Dept Mental Hlth, Aberdeen AB9 2ZD, Scotland Univ Aberdeen Aberdeen Scotland AB9 2ZD Hlth, Aberdeen AB9 2ZD, Scotland
Titolo Testata:
CYTOKINE
fascicolo: 4, volume: 13, anno: 2001,
pagine: 253 - 255
SICI:
1043-4666(20010221)13:4<253:CPAI6R>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
PSYCHIATRIC CONSEQUENCES; TRAFFIC ACCIDENTS;
Keywords:
C-reactive protein; soluble interleukin 6 receptor; PTSD; trauma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Sutherland, AG Univ Aberdeen, Sch Med, Dept Orthopaed, Polwarth Bldg, Aberdeen AB9 2ZD, Scotland Univ Aberdeen Polwarth Bldg Aberdeen Scotland AB9 2ZD land
Citazione:
R.J. Miller et al., "C-reactive protein and interleukin 6 receptor in post-traumatic stress disorder: A pilot study", CYTOKINE, 13(4), 2001, pp. 253-255

Abstract

Background: it has been reported that psychological stress in humans is associated with a derangement of biological homeostasis, This pilot study aimed to examine the inflammatory response to post-traumatic stress disorder (PTSD) through measurements of the serum levels of the receptor to interleukin 6 (sIL-6r) and C-reactive protein (CRP), in relation to measures of psychological disturbance, Methods: 15 patients with established PTSD and eightcontrol patients with musculoskeletal injuries were studied at least threemonths after their index trauma. All completed revised impact of events scale (RIES), Davidson's trauma scale (DTS) and the general health questionnaire (GHQ), and gave blood samples that were assayed for CRP and sIL-6r, Statistical analysis was by the Mann-Whitney U-Wilcoxon rank sum tests, Results: positive relationships were found between sIL-6r and the RIES intrusion score (P = 0.026), and between CRP and DTS intrusion scores (P = 0.016), GHQ depression (P = 0.028), and RIES intrusion (P = 0.044) in the case group,Discussion: we have demonstrated a relationship between post-traumatic psychological and biological disturbance, which provides the basis for furtherresearch on the effects of psychological disturbance on physical recovery after injury, (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 12:04:15