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Titolo:
Interleukin 15 stimulates production of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 by human peripheral blood mononuclear cells
Autore:
Constantinescu, CS; Grygar, C; Kappos, L; Leppert, D;
Indirizzi:
Univ Nottingham Hosp, Queens Med Ctr, Div Clin Neurol, Nottingham NG7 2UH,England Univ Nottingham Hosp Nottingham England NG7 2UH ttingham NG7 2UH,England Univ Hosp, Dept Neurol, Basel, Switzerland Univ Hosp Basel SwitzerlandUniv Hosp, Dept Neurol, Basel, Switzerland Univ Hosp, Dept Res, Basel, Switzerland Univ Hosp Basel SwitzerlandUniv Hosp, Dept Res, Basel, Switzerland
Titolo Testata:
CYTOKINE
fascicolo: 4, volume: 13, anno: 2001,
pagine: 244 - 247
SICI:
1043-4666(20010221)13:4<244:I1SPOM>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
MULTIPLE-SCLEROSIS; EXPRESSION; CYTOKINE; ACTIVATION; ARTHRITIS; MIGRATION; DISEASE;
Keywords:
interleukin 12; interleukin 15; matrix metalloproteinases; tissue inhibitor of matrix metalloproteinases;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Constantinescu, CS Univ Nottingham Hosp, Queens Med Ctr, Div Clin Neurol, Med Sch Bldg,B Floor, Nottingham NG7 2UH, England Univ Nottingham Hosp Med Sch Bldg,B Floor Nottingham England NG7 2UH
Citazione:
C.S. Constantinescu et al., "Interleukin 15 stimulates production of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 by human peripheral blood mononuclear cells", CYTOKINE, 13(4), 2001, pp. 244-247

Abstract

In peripheral blood mononuclear cells (PBMC), matrix metalloproteinase (MMP)-9 mediates the extravasation of immune cells and may be involved in tissue destruction during inflammation. We investigated the effect of the pro-inflammatory cytokines interleukin (IL-)12 and 15 on the secretion of MMP-9 in PBMC, IL-15, but not IL-12, induces MMP-9 in PBMC and in T cells. Moreover, the combination of IL-15 and IL-2 had an additive effect. In contrast, both IL-12 and IL-15 induced the release of tissue inhibitor of metalloproteinases (TIMP)-1, IL-15 led to a dose-dependent increase of the MMP-9/TIMP-1 ratio as a measure for increased proteolytic capacity, We conclude that IL-15 mediates its effects in inflammation in part through MMP-9. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/06/20 alle ore 01:12:28