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Titolo:
Nature's carbohydrate chemists: The enzymatic glycosylation of bioactive bacterial metabolites
Autore:
Thorson, JS; Hosted, TJ; Jiang, JQ; Biggins, JB; Ahlert, J;
Indirizzi:
Mem Sloan Kettering Canc Ctr, Mol Pharmacol & Therapeut Program, Lab Biosynth Chem, New York, NY 10021 USA Mem Sloan Kettering Canc Ctr New York NY USA 10021 New York, NY 10021 USA Cornell Univ, Sloan Kettering Div, Joan & Sanford Weill Grad Sch Med Sci 1, New York, NY 10021 USA Cornell Univ New York NY USA 10021 Sch Med Sci 1, New York, NY 10021 USA
Titolo Testata:
CURRENT ORGANIC CHEMISTRY
fascicolo: 2, volume: 5, anno: 2001,
pagine: 139 - 167
SICI:
1385-2728(200102)5:2<139:NCCTEG>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
BIOSYNTHETIC GENE-CLUSTER; STREPTOMYCES-VIOLACEORUBER TU22; ANTITUMOR ANTIBIOTIC HEDAMYCIN; POTENT COUMARIN INHIBITORS; DESIGNED SUGAR MOIETY; 50S RIBOSOMAL-SUBUNIT; RNA APTAMER COMPLEX; HEAD-TO-HEAD; CALICHEAMICIN OLIGOSACCHARIDE; SACCHAROPOLYSPORA-ERYTHRAEA;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
190
Recensione:
Indirizzi per estratti:
Indirizzo: Thorson, JS Mem Sloan Kettering Canc Ctr, Mol Pharmacol & Therapeut Program, Lab Biosynth Chem, 1275 York Ave,Box 309, New York, NY 10021 USA Mem Sloan Kettering Canc Ctr 1275 York Ave,Box 309 New York NY USA 10021
Citazione:
J.S. Thorson et al., "Nature's carbohydrate chemists: The enzymatic glycosylation of bioactive bacterial metabolites", CURR ORG CH, 5(2), 2001, pp. 139-167

Abstract

A recent estimate suggests roughly 70% of current lead compounds in modem drug discovery derive directly from the natural products, many of which areglycosylated bacterial metabolites. Thus, bacterial glycosyltransferases and their corresponding sugar substrates contribute significantly to the diversity of pharmaceutically important metabolites. This review summarizes (i) the role that carbohydrates contribute to biologically active bacterial metabolites, (ii) a sequence homology classification of known glycosyltransferases from these systems and (iii) the potential impact pathway engineering and combinatorial biocatalysis may have on increasing carbohydrate-liganddiversity. While the number of glycosylated bacterial metabolites is vast,this review limits itself to glycosides with considerable published information pertaining to biological activity and biosynthesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 14:11:56