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Titolo:
An fMRI study of the functional neuroanatomy of picture encoding in younger and older adults
Autore:
Iidaka, T; Sadato, N; Yamada, H; Murata, T; Omori, M; Yonekura, Y;
Indirizzi:
Fukui Med Univ, Biomed Imaging Res Ctr, Fukui 9101193, Japan Fukui Med Univ Fukui Japan 9101193 Imaging Res Ctr, Fukui 9101193, Japan Natl Inst Physiol Sci, Okazaki, Aichi 4448585, Japan Natl Inst Physiol Sci Okazaki Aichi Japan 4448585 i, Aichi 4448585, Japan Fukui Med Univ, Dept Radiol, Fukui 9101193, Japan Fukui Med Univ Fukui Japan 9101193 iv, Dept Radiol, Fukui 9101193, Japan Fukui Med Univ, Dept Neuropsychiat, Fukui 9101193, Japan Fukui Med Univ Fukui Japan 9101193 t Neuropsychiat, Fukui 9101193, Japan
Titolo Testata:
COGNITIVE BRAIN RESEARCH
fascicolo: 1, volume: 11, anno: 2001,
pagine: 1 - 11
SICI:
0926-6410(200103)11:1<1:AFSOTF>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; AGE-RELATED DIFFERENCES; ALZHEIMERS-DISEASE; NEURAL ACTIVITY; PREFRONTAL ACTIVATION; RECOGNITION MEMORY; EPISODIC MEMORY; FRONTAL-CORTEX; HUMAN BRAIN; RETRIEVAL;
Keywords:
episodic memory; parietal lobe; concrete picture; abstract picture; neuroimaging; aging;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Iidaka, T Nagoya Univ, Sch Informat & Sci, Nagoya, Aichi 4648601, Japan Nagoya Univ Nagoya Aichi Japan 4648601 ya, Aichi 4648601, Japan
Citazione:
T. Iidaka et al., "An fMRI study of the functional neuroanatomy of picture encoding in younger and older adults", COGN BRAIN, 11(1), 2001, pp. 1-11

Abstract

Age-related changes in the neural mechanisms of picture encoding were investigated using functional magnetic resonance imaging (fMRI). Seven younger and seven older adults were studied while they were encoding pairs of concrete-related, concrete-unrelated, and abstract pictures. Functional (T2*-weighted) acid anatomical (T1-weighted) images of the brain were obtained using a 1.5 T MRI scanner. The results in the younger adults showed that the left dorsal prefrontal cortex (PFC) was activated during associative learningof the concrete-unrelated or abstract pictures. The results also suggest that both ventral and dorsal visual pathways are involved in the encoding ofabstract pictures, and that the right superior parietal lobule likely mediates spatial information of the abstract pictures. The older adults showed significant activation in the left dorsal PFC under concrete-unrelated and abstract conditions. However, the older adults failed to activate either the left ventral and right dorsal PFC under the concrete-unrelated condition,or the parietal areas under abstract condition. A direct comparison between the two age groups demonstrates that the older adults had a reduced activation in the bilateral parieto-temporo-occipital areas under abstract condition, and in the right temporo-occipital area extending to the fusiform gyrus under the concrete-unrelated condition. Finally, age difference was found in correlation between memory performance and amplitude of signal change in the parahippocampal gyrus and fusiform gyrus under the concrete-unrelated and abstract conditions. These changes in neural response likely underliethe age-related memory decline in relation to pictorial information. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 27/01/20 alle ore 14:23:23