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Titolo:
Potentials recorded at the scalp by stimulation near the human subthalamicnucleus
Autore:
Ashby, P; Paradiso, G; Saint-Cyr, JA; Chen, R; Lang, AE; Lozano, AM;
Indirizzi:
Univ Toronto, Toronto Western Hosp, Res Inst, Movement Disorder Clin, Toronto, ON M5T 2S8, Canada Univ Toronto Toronto ON Canada M5T 2S8 Clin, Toronto, ON M5T 2S8, Canada
Titolo Testata:
CLINICAL NEUROPHYSIOLOGY
fascicolo: 3, volume: 112, anno: 2001,
pagine: 431 - 437
SICI:
1388-2457(200103)112:3<431:PRATSB>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADVANCED PARKINSONS-DISEASE; ELECTRICAL-STIMULATION; BASAL GANGLIA; MOTOR CORTEX; PALLIDUM; TREMOR;
Keywords:
evoked potentials; subthalamic nucleus; scalp potentials; stimulus parameters; Parkinson's disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Ashby, P Univ Toronto, Toronto Western Hosp, Res Inst, Movement Disorder Clin, EC8 005,399 Bathurst St, Toronto, ON M5T 2S8, Canada Univ Toronto EC8 005,399 Bathurst St Toronto ON Canada M5T 2S8 da
Citazione:
P. Ashby et al., "Potentials recorded at the scalp by stimulation near the human subthalamicnucleus", CLIN NEU, 112(3), 2001, pp. 431-437

Abstract

Objective: To record the potentials evoked at the scalp by stimulation through electrodes targeted at the human subthalamic nucleus (STN) and to determine whether the responsible pathways continue to be excited or become blocked with high frequency stimulation. Methods: We recorded the potentials evoked at the scalp in response to single and multiple stimuli delivered through STN contacts in 6 patients with Parkinson's disease. Results: On 9/11 sides tested, single stimuli elicited a negative potential with latency of similar to3 ms which was largest over the frontal region. Its short chronaxie (50 mus) and refractory period imply that it arose from the activation of low threshold neural elements, possibly myelinated axons. This potential could follow at 100 Hz. This early potential was sometimes followed by later negative potentials at similar to5 ms (6/11 sides) and similar to8 ms (8/11 sides). The responsible neural elements had the same short chronaxie. These potentials were augmented by paired stimuli at separations of 2-7 ms and by trains of stimuli at 200 Hz. Conclusions: Trains of stimuli delivered to the STN may excite low threshold neural elements which can transmit impulses at frequencies >100 Hz without blocking and which may produce postsynaptic facilitation at the cortex. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 22:27:34