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Titolo:
Dipole modeling of scalp electroencephalogram epileptic discharges: correlation with intracerebral fields
Autore:
Merlet, I; Gotman, J;
Indirizzi:
McGill Univ, Montreal Neurol Inst, Dept Neurol & Neurosurg, Montreal, PQ H3A 2B4, Canada McGill Univ Montreal PQ Canada H3A 2B4 surg, Montreal, PQ H3A 2B4, Canada
Titolo Testata:
CLINICAL NEUROPHYSIOLOGY
fascicolo: 3, volume: 112, anno: 2001,
pagine: 414 - 430
SICI:
1388-2457(200103)112:3<414:DMOSEE>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
TEMPORAL-LOBE EPILEPSY; REALISTICALLY SHAPED HEAD; REFRACTORY PARTIAL EPILEPSY; SOURCE LOCALIZATION; INTERICTAL SPIKES; 3-DIMENSIONAL LOCALIZATION; HUMAN BRAIN; ACCURACY; PROPAGATION; RELIABILITY;
Keywords:
seizures; dipole modeling; scalp electroencephalogram; intracerebral recordings;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Gotman, J McGill Univ, Montreal Neurol Inst, Dept Neurol & Neurosurg, 3801Univ St, Montreal, PQ H3A 2B4, Canada McGill Univ 3801 Univ St Montreal PQCanada H3A 2B4 2B4, Canada
Citazione:
I. Merlet e J. Gotman, "Dipole modeling of scalp electroencephalogram epileptic discharges: correlation with intracerebral fields", CLIN NEU, 112(3), 2001, pp. 414-430

Abstract

Objective: In order to evaluate the feasibility of modeling seizures and the reliability of dipole models, we compared source localizations of scalp seizures with the distribution of simultaneous intracerebral electroencephalogram (SEEG). Methods: In a first session, only scalp electroencephalogram (EEG) was recorded from 15 patients. We averaged the first detectable ictal activity in two consecutive segments of stable topography and morphology. Spatio-temporal dipole sources were estimated for each segment and projected on 3D-magnetic resonance images. In a second session, SEEG was recorded simultaneouslywith control scalp electrodes, allowing the identification of ictal patterns similar to those submitted to dipole modeling. Results: Ictal discharges could be analyzed in only 6 of 15 patients. In the remaining 9, scalp discharges were undetectable or nonreproducible in 6,and solutions were unstable despite an apparently stable discharge in 3. In the 6 patients successfully modeled, dipoles were found in regions where SEEG discharges were present. However, when intracerebral discharges were very focal, there was no corresponding scalp activity. When intracerebral signals were maximal in the mesial temporal regions at the seizure onset, only lateral neocortical dipoles were found. When discharges reached the frontal lobes, we could identify lateral and mesial frontal sources. Conclusions: In most seizures, it was not possible to obtain satisfactory dipole models, probably a reflection of the high noise level or widespread generators. When modeling was possible, our results suggested that mesial temporal seizure discharges did not contribute to scalp EEG activity. This activity appears to reflect signals synchronized and distributed over the lateral temporal or frontal neocortex, as well as signals generated in mesialfrontal areas. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

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Documento generato il 29/03/20 alle ore 18:03:54