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Titolo:
Tissue transglutaminase and endomysial antibodies - Diagnostic markers of gluten-sensitive enteropathy in dermatitis herpetiformis
Autore:
Kumar, V; Jarzabek-Chorzelska, M; Sulej, J; Rajadhyaksha, M; Jablonska, S;
Indirizzi:
IMMCO Diagnost Inc, Buffalo, NY 14228 USA IMMCO Diagnost Inc Buffalo NY USA 14228 agnost Inc, Buffalo, NY 14228 USA SUNY Buffalo, Dept Microbiol, Buffalo, NY 14214 USA SUNY Buffalo Buffalo NY USA 14214 , Dept Microbiol, Buffalo, NY 14214 USA SUNY Buffalo, Dept Dermatol, Buffalo, NY 14214 USA SUNY Buffalo Buffalo NY USA 14214 o, Dept Dermatol, Buffalo, NY 14214 USA Warsaw Med Sch, Dept Dermatol, Warsaw, Poland Warsaw Med Sch Warsaw Poland saw Med Sch, Dept Dermatol, Warsaw, Poland
Titolo Testata:
CLINICAL IMMUNOLOGY
fascicolo: 3, volume: 98, anno: 2001,
pagine: 378 - 382
SICI:
1521-6616(200103)98:3<378:TTAEA->2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELIAC-DISEASE; ANTI-ENDOMYSIUM; AUTOANTIBODIES; AUTOANTIGEN; IDENTIFICATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Kumar, V IMMCO Diagnost Inc, Buffalo, NY 14228 USA IMMCO Diagnost Inc Buffalo NY USA 14228 c, Buffalo, NY 14228 USA
Citazione:
V. Kumar et al., "Tissue transglutaminase and endomysial antibodies - Diagnostic markers of gluten-sensitive enteropathy in dermatitis herpetiformis", CLIN IMMUNO, 98(3), 2001, pp. 378-382

Abstract

The association of Durhing's disease, commonly referred to as dermatitis herpetiformis (DH), with gluten-sensitive enteropathy (GSE) is supported by the presence of villous atrophy and endomysial antibodies (EMA), EMA are found to be a marker of GSE both in celiac disease (CD) and in DH. Since tissue transglutaminase (tTG) is believed to be the major autoantigen in GSE, the aim of our study was to determine the specificity and sensitivity of anti-tTG antibody ELISA compared to the EMA indirect immunofluorescence test. We studied 44 cases of DH, confirmed by the presence of IgA immune depositsin the dermal papillae, and 58 cases of CD conforming to the InternationalCriteria of Diagnosing CD, The control group comprised 161 sera from patients with vesiculobullous disorders other than DH and 106 sera from normal healthy blood donors, Anti-tTG antibodies were detected in 36 of 44 DH (79%)and in 32 of 58 CD (55%) patients. EMA were positive in 33 of 44 DH (74%) and in 36 of 58 CD (62%) patients. Both the EMA and the antibodies to tTG were present in the majority of patients with DH and CD when they were on a normal gluten-containing diet and were absent when on a gluten-free diet for an extended period of time. There were, however, small discrepancies in positivity and negativity in tTG antibody-positive and EMA-negative patientsand vice versa. There seems to be a correlation between the EMA titers andthe anti-tTG antibody levels. This study confirms the high specificity andsensitivity of anti-tTG antibody ELISA for GSE and its strong correlation with EMA both in CD and in DH. The results of anti-tTG antibody and EMA assays were comparable; however, in DH, tTG was somewhat more sensitive than the EMA test. For screening of DH, it is advisable to perform both EMA and anti-tTG antibody tests. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/05/20 alle ore 15:48:40