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Titolo:
Morphine modulation of the contact hypersensitivity response: Characterization of immunological changes
Autore:
Nelson, CJ; Lysle, DT;
Indirizzi:
Univ N Carolina, Dept Psychol, Chapel Hill, NC 27599 USA Univ N Carolina Chapel Hill NC USA 27599 ychol, Chapel Hill, NC 27599 USA
Titolo Testata:
CLINICAL IMMUNOLOGY
fascicolo: 3, volume: 98, anno: 2001,
pagine: 370 - 377
SICI:
1521-6616(200103)98:3<370:MMOTCH>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
DELAYED-TYPE HYPERSENSITIVITY; NITRIC-OXIDE; MAST-CELLS; OPIATE RECEPTORS; IMMUNE-SYSTEM; LYMPHOCYTES-T; CYTOKINES; IL-6; INVOLVEMENT; ELICITATION;
Keywords:
morphine; contact hypersensitivity; iNOS; IL-6; IL-10; lymphocyte proliferation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Nelson, CJ Univ N Carolina, Dept Psychol, CB 3270, Chapel Hill, NC 27599 USA Univ N Carolina CB 3270 Chapel Hill NC USA 27599 , NC 27599 USA
Citazione:
C.J. Nelson e D.T. Lysle, "Morphine modulation of the contact hypersensitivity response: Characterization of immunological changes", CLIN IMMUNO, 98(3), 2001, pp. 370-377

Abstract

Previous investigations in our laboratory showed that systemic morphine administration 1 h prior to elicitation of the in vivo contact hypersensitivity (CHS) response produced a robust increase in inflammation at the site ofantigen reexposure. The present study extended those findings by characterizing the effect of morphine on immunological processes important in the development of the CHS response, To induce contact hypersensitivity, the antigen 2,4-dinitrofluorobenzene was applied to the pinnae of previously sensitized rats. Morphine administration produced an increase in inducible nitricoxide synthase mRNA and the proinflammatory cytokine interleukin-g, at thesite of antigen reexposure. In contrast, morphine did not alter expressionof the anti-inflammatory cytokine interleukin-10. Morphine also produced an increase in the proliferation of lymphocytes from the peripheral (i.e., cervical) lymph nodes when assessed 72 h following challenge. These studies show that the morphine-induced increase in the in vivo CHS response involves immunologically specific alterations. (C) 2001 Academic Press.

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Documento generato il 04/04/20 alle ore 11:41:02