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Titolo:
Human gamma delta T cells express a higher TCR/CD3 complex density than alpha beta T cells
Autore:
Nicolas, L; Monneret, G; Debard, AL; Blesius, A; Gutowski, MC; Salles, G; Bienvenu, J;
Indirizzi:
Ctr Hosp Lyon Sud, Immunol Lab, Lyon, France Ctr Hosp Lyon Sud Lyon France Hosp Lyon Sud, Immunol Lab, Lyon, France Ctr Hosp Lyon Sud, Dept Hematol, Lyon, France Ctr Hosp Lyon Sud Lyon France Hosp Lyon Sud, Dept Hematol, Lyon, France Ctr Hosp Lyon Sud, UPRES JE Pathol Cellules Lymphoides, Lyon, France Ctr Hosp Lyon Sud Lyon France Pathol Cellules Lymphoides, Lyon, France
Titolo Testata:
CLINICAL IMMUNOLOGY
fascicolo: 3, volume: 98, anno: 2001,
pagine: 358 - 363
SICI:
1521-6616(200103)98:3<358:HGDTCE>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECOGNITION; PROTECTION; NECROSIS; IMMUNITY;
Keywords:
gamma delta T cells; CD3; TCR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Nicolas, L Ctr Hosp Lyon Sud, Immunol Lab, Lyon, France Ctr Hosp Lyon SudLyon France Sud, Immunol Lab, Lyon, France
Citazione:
L. Nicolas et al., "Human gamma delta T cells express a higher TCR/CD3 complex density than alpha beta T cells", CLIN IMMUNO, 98(3), 2001, pp. 358-363

Abstract

The aim of our study was to compare CD3 expression on gamma delta T cells and alpha beta T cells in human patients. The antigen density of TCR and CD3 on both subsets was assessed by a quantitative method in eight patients. In parallel, we developed and validated a reliable direct tricolor stainingprotocol that we tested on samples from hospitalized and healthy individuals (n = 60). Our results demonstrate that human gamma delta T cells constitutively express approximately twofold more of the TCR/CD3 complex than alpha beta T cells. We suggest that this enhanced expression of the TCR/CD3 complex could contribute to the higher reactivity of gamma delta T cells compared to alpha beta T cells. These clinical laboratory results confirm the fundamental data described elsewhere. gamma delta T cells deserve further clinical investigations to understand their precise role in human immunity. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/05/20 alle ore 13:51:08