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Titolo:
Characteristics of an albumin cobalt binding test for assessment of acute coronary syndrome patients: A multicenter study
Autore:
Christenson, RH; Duh, SH; Sanhai, WR; Wu, AHB; Holtman, V; Painter, P; Branham, E; Apple, FS; Murakami, M; Morris, DL;
Indirizzi:
Univ Maryland, Sch Med, Dept Pathol, Baltimore, MD 21201 USA Univ Maryland Baltimore MD USA 21201 Dept Pathol, Baltimore, MD 21201 USA Univ Maryland, Sch Med, Dept Med & Res Technol, Baltimore, MD 21201 USA Univ Maryland Baltimore MD USA 21201 Res Technol, Baltimore, MD 21201 USA Hartford Hosp, Dept Pathol & Lab Med, Ishikari, Hokkaido 06102, Japan Hartford Hosp Ishikari Hokkaido Japan 06102 hikari, Hokkaido 06102, Japan Univ Tennessee, Med Ctr, Dynacare Tennesee, Knoxville, TN 37920 USA Univ Tennessee Knoxville TN USA 37920 e Tennesee, Knoxville, TN 37920 USA Univ Minnesota, Sch Med, Minneapolis, MN 55415 USA Univ Minnesota Minneapolis MN USA 55415 ch Med, Minneapolis, MN 55415 USA Hennepin Cty Med Ctr, Dept Lab Med & Pathol, Minneapolis, MN 55415 USA Hennepin Cty Med Ctr Minneapolis MN USA 55415 , Minneapolis, MN 55415 USA Ischemia Technol, Denver, CO 80221 USA Ischemia Technol Denver CO USA 80221 chemia Technol, Denver, CO 80221 USA
Titolo Testata:
CLINICAL CHEMISTRY
fascicolo: 3, volume: 47, anno: 2001,
pagine: 464 - 470
SICI:
0009-9147(200103)47:3<464:COAACB>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
CREATINE-KINASE-MB; CARDIAC TROPONIN-I; MYOCARDIAL-ISCHEMIA; RISK STRATIFICATION; TISSUE-INJURY; INFARCTION; DIAGNOSIS; ASSAY; THROMBOLYSIS; MYOGLOBIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Christenson, RH Univ Maryland, Med Ctr, 22 S Greene St, Baltimore, MD 21201 USA Univ Maryland 22 S Greene St Baltimore MD USA 21201 01 USA
Citazione:
R.H. Christenson et al., "Characteristics of an albumin cobalt binding test for assessment of acute coronary syndrome patients: A multicenter study", CLIN CHEM, 47(3), 2001, pp. 464-470

Abstract

Background: The ability of the N-terminal region of human albumin to bind cobalt is diminished by myocardial ischemia. The characteristics of an assay based on albumin cobalt binding were assessed in suspected acute coronarysyndrome patients and in a control reference population. The ability of the Albumin Cobalt Binding (ACB(TM)) Test measurement at presentation to predict troponin-positive or -negative results 6-24 h later was also examined. Methods: We enrolled 256 acute coronary syndrome patients at four medical centers. Blood specimens were collected at presentation and then 6-24 h later. The dichotomous decision limit and performance characteristics of the ACB Test for predicting troponin-positive or -negative status 6 h-24 h laterwere determined using ROC curve analysis. Results for 32 patients could not be used because the time of onset of ischemia appeared to have been >3 h before presentation or was uncertain. The reference interval was determinedby parametric analysis to estimate the upper 95th percentile of a reference population (n = 109) of ostensibly healthy individuals. Results: Increased cTnI was found in 35 of 224 patients. The ROC curve area for the ACB Test was 0.78 [95% confidence interval (CI), 0.70-0.86]. At the optimum decision point of 75 units/mL, the sensitivity and specificity of the ACB Test were 83% (95% CI, 66-93%) and 69% (95% CI, 62-76%). The negative predictive value was 96% (95% CI, 91-98%), and the positive predictivevalue was 33% (95% CI, 24-44%). The within-run CV of the ACB Test was 7.3%. Results for the reference population were normally distributed; the one-sided parametric 95th percentile was 80.2 units/mL. Conclusions: This exploratory study suggests that the ACB Test has high negative predictive value and sensitivity in the presentation sample for predicting troponin-negative or -positive results 6-24 h later. (C) 2001 American Association for Clinical Chemistry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 12:58:36