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Titolo:
Type III procollagen N-terminal propeptide, soluble interleukin-2 receptor, and von Willebrand factor in systemic sclerosis
Autore:
Lee, YJ; Shin, KC; Kang, SW; Lee, EB; Kim, HA; Song, YW;
Indirizzi:
Seoul Natl Univ Hosp, Dept Internal Med, Coll Med, Clin Res Inst,Chongno Gu, Seoul 110744, South Korea Seoul Natl Univ Hosp Seoul South Korea 110744 Seoul 110744, South Korea Chungnam Natl Univ, Taejon, South Korea Chungnam Natl Univ Taejon South Korea am Natl Univ, Taejon, South Korea
Titolo Testata:
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
fascicolo: 1, volume: 19, anno: 2001,
pagine: 69 - 74
SICI:
0392-856X(200101/02)19:1<69:TIPNPS>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
VONWILLEBRAND-FACTOR ANTIGEN; CLINICAL-SIGNIFICANCE; RAYNAUDS-PHENOMENON; PULMONARY FIBROSIS; RACIAL-DIFFERENCES; LUNG INVOLVEMENT; DISEASE-ACTIVITY; SERUM; SCLERODERMA; PEPTIDE;
Keywords:
PIIINP; sIL-2R; vWF; systemic sclerosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Song, YW Seoul Natl Univ Hosp, Dept Internal Med, Coll Med, Clin Res Inst,Chongno Gu, Yongon Dong 28, Seoul 110744, South Korea Seoul Natl Univ Hosp Yongon Dong 28 Seoul South Korea 110744 rea
Citazione:
Y.J. Lee et al., "Type III procollagen N-terminal propeptide, soluble interleukin-2 receptor, and von Willebrand factor in systemic sclerosis", CLIN EXP RH, 19(1), 2001, pp. 69-74

Abstract

ObjectiveTo evaluate the blood concentration of type III procollagen N-terminal propeptide (PIIINP), soluble interleukin-2 receptor (sIL-2R), and von Willebrand factor (VWF) in systemic sclerosis (SSc) patients. MethodsPIIINP sIL-2R, and vWF were measured in the sera and plasma of 29 SSc patients and 29 sex and age-matched healthy controls. Serum PIIINP was determined by radioimmunoassay. Both serum sIL-2R and plasma vWF were measured by enzyme-linked immunosorbent assay (ELISA). Associations between concentrations and clinical and laboratory features were evaluated. ResultsSerum levels of PIIINP and sIL-2R were significantly higher in the SSc group than in the control group (p < 0.01 for both). No differences in serum PIIINP and sIL-2R levels were found between the limited and diffuse cutaneous subsets. However PIIINP concentrations were significantly higher in anti-Scl-70 positive SSc patients compared with those of anti-Scl-70 negative patients (p = 0. 01). Serum PIIINP levels were significantly higher in SSc patients with restrictive pulmonary function (FVC < 80%) than in patients with normal pulmonary function (p < 0.05). The correlation between PIIINP levels and FVC (p < 0.05) was negative, but the correlation between PIIINP levels and modified Rodnan skin scores (p < 0.05) was positive. sIL-2R levels were not correlated with skin and pulmonary involvement of SSc. There was nodifference in vWF levels between those of the SSc patients and those of the control groups. ConclusionThese results suggest that serum PIIINP serves as a biologic marker for the extent of skin and pulmonary involvement in systemic sclerosis. Increasedserum levels of sIL-2R in SSc patients support a role for T lymphocyte activation in the pathogenesis of systemic sclerosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/21 alle ore 03:56:53