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Titolo:
Dehydroepiandrosterone sulphate serum levels in systemic sclerosis
Autore:
La Montagna, G; Baruffo, A; Buono, G; Valentini, G;
Indirizzi:
Univ Naples 2, Cattedra & Div Reumatol, Fac Med, I-80131 Naples, Italy Univ Naples 2 Naples Italy I-80131 matol, Fac Med, I-80131 Naples, Italy
Titolo Testata:
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
fascicolo: 1, volume: 19, anno: 2001,
pagine: 21 - 26
SICI:
0392-856X(200101/02)19:1<21:DSSLIS>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
SULFATE DHEAS LEVELS; RHEUMATOID-ARTHRITIS; LUPUS-ERYTHEMATOSUS; SCLERODERMA; BLOOD; PATHOGENESIS; ANDROGENS; MECHANISM; CORTISOL; COLLAGEN;
Keywords:
dehydroepiandrosterone sulphate; systemic sclerosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: La Montagna, G Univ Naples 2, Cattedra & Div Reumatol, Fac Med, Via SergioPansini 5, I-80131 Naples, Italy Univ Naples 2 Via Sergio Pansini 5 Naples Italy I-80131 ly
Citazione:
G. La Montagna et al., "Dehydroepiandrosterone sulphate serum levels in systemic sclerosis", CLIN EXP RH, 19(1), 2001, pp. 21-26

Abstract

ObjectiveTo evaluate in a cohort of women with systemic sclerosis (SSc) the dehydroepiandrosterone sulphate (DHEAS) serum levels and their relationship with disease severityMethodsDHEAS serum concentrations were measured by radioimmmunoassay in 40 SSc patients and compared with those in 40 controls matched for sex and reproductive status. IL-2 sR alpha was evaluated as a disease activity index. A preliminary organ/system severity scale proposed by Medsger et al. in 1999 was used to evaluate disease severityResultsMean serum levels of DHEAS in SSe women of childbearing age were significantly lower than in controls (0.87 +/- 0.85 mug/ml versus 2. 75 + 0.42 mug/ml; p < 0.001). On the contrary, no difference was found between postmenopausal women and controls. A reduction below the 95% confidence limits was found in 10 out of 11 patients of childbearing age and in 8 out of 29 postmenopausal women, respectively. In 5 out of 11 patients of childbearing age taking steroids for their SSc (< 10 mg/daily) DHEAS levels were significantly lower than in patients not taking steroids (p = 0.01). On the contrary, 16 out of 29 postmenopausal women using steroids had lower DHEAS concentrations than in patients not taking steroids, although the difference was not statistically significant. There was no statistically significant difference in DHEAS levels between patients with diffuse or limited SSc, or between those with or without organ system involvement. No correlations were found either in pre- and post-menopausal steroid nonusers, or in limited and diffusesubsets, between DHEAS levels and age, postmenopausal years, disease duration, IL-2 sRa, disease organ/system severity scale. ConclusionOur data show that, as in other autoimmune diseases, low serum DHEAS is a feature of premenopausal SSe patients. More extensive prospective studies are needed to define the exact role of DHEAS dysregulation in SSc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 12:41:13