Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The dopaminergic system in hypertension
Autore:
Amenta, F; Ricci, A; Rossodivita, I; Avola, R; Tayebati, SK;
Indirizzi:
Univ Camerino, Dipartimento Sci Farmacol & Med Sperimentale, Sez Anat Umana, I-62032 Camerino, Italy Univ Camerino Camerino Italy I-62032 Anat Umana, I-62032 Camerino, Italy Univ La Sapienza, Dipartimento Sci Cardiovasc & Resp, I-00161 Rome, Italy Univ La Sapienza Rome Italy I-00161 rdiovasc & Resp, I-00161 Rome, Italy Univ Catania, Dipartimento Chim, Sez Biochim, I-95125 Catania, Italy Univ Catania Catania Italy I-95125 , Sez Biochim, I-95125 Catania, Italy
Titolo Testata:
CLINICAL AND EXPERIMENTAL HYPERTENSION
fascicolo: 1-2, volume: 23, anno: 2001,
pagine: 15 - 24
SICI:
1064-1963(200101/02)23:1-2<15:TDSIH>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERIPHERAL-BLOOD LYMPHOCYTES; NA+-H+ EXCHANGER; RENAL DOPAMINE; RADIOLIGAND BINDING; D-2-LIKE RECEPTORS; ADENYLATE-CYCLASE; MOLECULAR-BIOLOGY; KIDNEY DOPAMINE; CAUDATE-NUCLEUS; D-3 RECEPTOR;
Keywords:
dopamine; hypertension; kidney; receptors; receptor coupling mechanisms;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Amenta, F Univ Camerino, Dipartimento Sci Farmacol & Med Sperimentale, SezAnat Umana, Via M Scalzino 3, I-62032 Camerino, Italy Univ Camerino Via M Scalzino 3 Camerino Italy I-62032 no, Italy
Citazione:
F. Amenta et al., "The dopaminergic system in hypertension", CLIN EXP HY, 23(1-2), 2001, pp. 15-24

Abstract

Dopamine exerts cardiovascular and renal actions mediated through interaction with specific dopamine receptors. Dopamine receptors are cell surface receptors coupled to G-proteins and classified into two main super families based on biochemical, pharmacological and molecular characteristics. The dopamine D1-like receptor super family includes D1 and D5 receptors, known also in rodents as DIA and DIB sites. These receptors are linked to stimulation of adenylate cyclase. The dopamine D2-like receptor super family includes D2, D3 and D4 receptors. These receptors are linked to inhibition of adenylate cylase or not related with this enzyme activity. They also interfere with opening of Ca+2 channels and are linked to stimulation of K+ receptors. Dopamine receptor subtypes are expressed in brain as well as in extracerebral structures such as the heart, blood vessels, carotid body, kidney, adrenal gland, parathyroid gland and gastrointestinal tract. In the kidney, which represents the peripheral organ where dopamine receptors were more extensively investigated, dopamine receptors are involved in regulation of hemodynamic, electrolyte and water transport, as well as renin secretion. Hypertension-related dopamine receptor changes were also investigated primarily in the kidney. Defective renal dopamine production and/ordopamine receptor function have been reported in human primary hypertension as well as in genetic models of animal hypertension. There may be a primary defect in D1-like receptors and an altered signalling system in the proximal tubules that lead to reduced dopamine-mediated effects on renal sodiumexcretion in hypertension. Studies on the influence of hypertension on dopamine D2-like receptors are sparse Disruption of either D1A or D3 receptorsat the gene level causes hypertension in mice. Using peripheral blood lymphocytes as possible markers of the status of dopamine receptors in essential hypertension, no changes of dopamine D1-like receptors were noticeable, whereas an increase of dopamine D2-like receptors likely representing an up-regulation mechanism was reported. Available information collectively indicates an involvement of peripheral dopaminergic system in hypertension consisting either in impaired receptor transduction mechanisms and/or in receptor loss. A better knowledge of molecular bases of these changes may contribute to the development of specific therapeutic approaches in the future.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 10:39:27